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CHEMBL1923617 (CID 57399248) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(1)
 
 
Unspecified(10)
 
 
Top Targets:
Motilin assoc(2)
 
 
BioAssay Types:
Literature(16)
 
 
 
 
BioActivity Types:
EC50(2)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 16    Data Row: 16   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136937635]
Ki 0.00035Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay [AID632805, Type: Literature]Appetite-regulating hormone [gi:17865471]
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2
[SID136937635]
Ki 0.001Agonist activity at ghrelin receptor [AID711464, Type: Literature]
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3
[SID136937635]
EC50 0.014Agonist activity at ghrelin receptor by cell based assay [AID711463, Type: Literature]
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4
[SID136937635]
EC50 0.02Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay [AID632806, Type: Literature]Appetite-regulating hormone [gi:17865471]
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5
[SID136937635]
Cmax in Sprague-Dawley rat at 8 mg/kg, po [AID632808, Type: Literature]
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6
[SID136937635]
AUC (0 to infinity) in Sprague-Dawley rat at 8 mg/kg, po [AID632809, Type: Literature]
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7
[SID136937635]
Elimination half life in Sprague-Dawley rat at 2 m/kg, iv [AID632810, Type: Literature]
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8
[SID136937635]
Volume of distribution at steady state in Sprague-Dawley rat at 2 m/kg, iv [AID632811, Type: Literature]
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9
[SID136937635]
Clearance in Sprague-Dawley rat at 2 m/kg, iv [AID632812, Type: Literature]
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10
[SID136937635]
Oral bioavailability in Sprague-Dawley rat at 2 mg/kg [AID632813, Type: Literature]
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11
[SID136937635]
Permeability across mucosal to serosal side in human Caco2 cells [AID632814, Type: Literature]
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12
[SID136937635]
Permeability across serosal to mucosal side human Caco2 cells [AID632815, Type: Literature]
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13
[SID136937635]
Drug metabolism in rat liver microsomes after 15 mins [AID632816, Type: Literature]
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14
[SID136937635]
Half life in human liver microsomes [AID632817, Type: Literature]
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15
[SID136937635]
Induction of gasrtic emptying in overnight-fasted iv dosed Wistar rat measured after 15 mins by calorimetric analysis [AID632989, Type: Literature]
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16
[SID136937635]
Induction of gasrtic emptying in overnight-fasted po dosed Wistar rat adiminstered 30 mins prior methylcellulose meal by calorimetric analysis [AID632990, Type: Literature]
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