CHEMBL1935608 (CID 57398720) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Unspecified(3)
 
 
Top Targets:
NR LBD PPAR(4)
 
 
 
BioAssay Types:
Literature(6)
 
 
 
BioActivity Types:
EC50(2)
 
 
IC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 6    Data Row: 6   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136936607]
EC50 0.03Transactivation of human full length PPARgamma expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay [AID637345, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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2
[SID136936607]
EC50 0.03Transactivation of human full length PPARgamma expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay [AID637345, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
3
[SID136936607]
EC50 0.03Transactivation of human full length PPARgamma expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay [AID637345, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
4
[SID136936607]
EC50 0.03Transactivation of human full length PPARgamma expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay [AID637345, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
5
[SID136936607]
EC50 0.1Transactivation of human full length PPARalpha expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay [AID637346, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
6
[SID136936607]
EC50 0.1Transactivation of human full length PPARalpha expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay [AID637346, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
7
[SID136936607]
IC50 0.95Inhibition of PTB1B using pNPP as substrate after 30 mins [AID637349, Type: Literature]
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8
[SID136936607]
 Hypoglycemic activity in diabetic KK-Ay mouse model assessed as decrease in glucose level at 10 mg/kg, po qd for 4 days relative to untreated control [AID637350, Type: Literature]
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9
[SID136936607]
 Transactivation of human full length PPARalpha expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay relative to WY14643 [AID637348, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
10
[SID136936607]
 Transactivation of human full length PPARalpha expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay relative to WY14643 [AID637348, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
11
[SID136936607]
 Transactivation of human full length PPARgamma expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay relative to farglitazar [AID637347, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
12
[SID136936607]
 Transactivation of human full length PPARgamma expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay relative to farglitazar [AID637347, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
13
[SID136936607]
 Transactivation of human full length PPARgamma expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay relative to farglitazar [AID637347, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
14
[SID136936607]
 Transactivation of human full length PPARgamma expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay relative to farglitazar [AID637347, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View