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CHEMBL1908392 (CID 57397989) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(257)
 
 
Unspecified(185)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
BioAssay Types:
Literature(442)
 
 
 
BioActivity Types:
Kd(442)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 442    Data Row: 442   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136935277]
Kd 0.00042Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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2
[SID136935277]
Kd 0.0007Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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3
[SID136935277]
Kd 0.00071Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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4
[SID136935277]
Kd 0.0018Binding constant for MEK5 kinase domain [AID624721, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 5 [gi:118572669]
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5
[SID136935277]
Kd 0.0022Binding constant for BIKE kinase domain [AID625109, Type: Literature]BMP-2-inducible protein kinase [gi:34222653]
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6
[SID136935277]
Kd 0.0026Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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7
[SID136935277]
Kd 0.0027Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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8
[SID136935277]
Kd 0.0029Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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9
[SID136935277]
Kd 0.0029Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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10
[SID136935277]
Kd 0.0036Binding constant for PKNB(M.tuberculosis) kinase domain [AID624753, Type: Literature]Serine/threonine-protein kinase PknB [gi:61229902]
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11
[SID136935277]
Kd 0.0038Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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12
[SID136935277]
Kd 0.0041Binding constant for TAK1 kinase domain [AID624724, Type: Literature]Mitogen-activated protein kinase kinase kinase 7 [gi:12643557]
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13
[SID136935277]
Kd 0.0045Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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14
[SID136935277]
Kd 0.0045Binding constant for TRKA kinase domain [AID624808, Type: Literature]High affinity nerve growth factor receptor [gi:94730402]
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15
[SID136935277]
Kd 0.0048Binding constant for JAK1(JH2domain-pseudokinase) kinase domain [AID624858, Type: Literature]Tyrosine-protein kinase JAK1 [gi:215274013]
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16
[SID136935277]
Kd 0.0049Binding constant for MELK kinase domain [AID625087, Type: Literature]Maternal embryonic leucine zipper kinase [gi:50400857]
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17
[SID136935277]
Kd 0.0052Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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18
[SID136935277]
Kd 0.0057Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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19
[SID136935277]
Kd 0.0062Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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20
[SID136935277]
Kd 0.0063Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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21
[SID136935277]
Kd 0.0082Binding constant for JAK3(JH1domain-catalytic) kinase domain [AID624785, Type: Literature]Tyrosine-protein kinase JAK3 [gi:50403745]
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22
[SID136935277]
Kd 0.0084Binding constant for PRP4 kinase domain [AID624750, Type: Literature]Serine/threonine-protein kinase PRP4 homolog [gi:317373526]
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23
[SID136935277]
Kd 0.0085Binding constant for MERTK kinase domain [AID624767, Type: Literature]Tyrosine-protein kinase Mer [gi:160332297]
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24
[SID136935277]
Kd 0.0088Binding constant for CLK1 kinase domain [AID624764, Type: Literature]Dual specificity protein kinase CLK1 [gi:206729857]
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25
[SID136935277]
Kd 0.009Binding constant for MST1 kinase domain [AID625055, Type: Literature]Serine/threonine-protein kinase 4 [gi:13124559]
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26
[SID136935277]
Kd 0.0094Binding constant for MAP3K2 kinase domain [AID625062, Type: Literature]Mitogen-activated protein kinase kinase kinase 2 [gi:97536681]
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27
[SID136935277]
Kd 0.0096Binding constant for RET(V804M) kinase domain [AID625124, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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28
[SID136935277]
Kd 0.0098Binding constant for RET(V804L) kinase domain [AID625123, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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29
[SID136935277]
Kd 0.01Binding constant for MEK1 kinase domain [AID624893, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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30
[SID136935277]
Kd 0.01Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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31
[SID136935277]
Kd 0.012Binding constant for SRPK3 kinase domain [AID625078, Type: Literature]SRSF protein kinase 3 [gi:332278151]
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32
[SID136935277]
Kd 0.012Binding constant for AXL kinase domain [AID624840, Type: Literature]Tyrosine-protein kinase receptor UFO [gi:239938818]
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33
[SID136935277]
Kd 0.012Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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34
[SID136935277]
Kd 0.014Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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35
[SID136935277]
Kd 0.014Binding constant for PRKG1 kinase domain [AID625052, Type: Literature]cGMP-dependent protein kinase 1 [gi:6225588]
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36
[SID136935277]
Kd 0.015Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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37
[SID136935277]
Kd 0.016Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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38
[SID136935277]
Kd 0.017Binding constant for PIP5K2B kinase domain [AID624915, Type: Literature]Phosphatidylinositol 5-phosphate 4-kinase type-2 beta [gi:47605991]
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39
[SID136935277]
Kd 0.017Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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40
[SID136935277]
Kd 0.017Binding constant for GRK4 kinase domain [AID624739, Type: Literature]G protein-coupled receptor kinase 4 [gi:143811400]
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41
[SID136935277]
Kd 0.018Binding constant for CLK4 kinase domain [AID625125, Type: Literature]Dual specificity protein kinase CLK4 [gi:34922132]
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42
[SID136935277]
Kd 0.018Binding constant for STK16 kinase domain [AID624775, Type: Literature]Serine/threonine-protein kinase 16 [gi:46577677]
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43
[SID136935277]
Kd 0.018Binding constant for LKB1 kinase domain [AID624798, Type: Literature]Serine/threonine-protein kinase STK11 [gi:3024670]
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44
[SID136935277]
Kd 0.019Binding constant for TRKB kinase domain [AID625032, Type: Literature]BDNF/NT-3 growth factors receptor [gi:2497560]
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45
[SID136935277]
Kd 0.021Binding constant for INSRR kinase domain [AID625075, Type: Literature]Insulin receptor-related protein [gi:12644000]
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46
[SID136935277]
Kd 0.021Binding constant for PCTK1 kinase domain [AID625033, Type: Literature]Cyclin-dependent kinase 16 [gi:266425]
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47
[SID136935277]
Kd 0.021Binding constant for SNARK kinase domain [AID625139, Type: Literature]NUAK family SNF1-like kinase 2 [gi:74761376]
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48
[SID136935277]
Kd 0.022Binding constant for TTK kinase domain [AID624910, Type: Literature]Dual specificity protein kinase TTK [gi:160112977]
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49
[SID136935277]
Kd 0.023Binding constant for RIOK1 kinase domain [AID625141, Type: Literature]Serine/threonine-protein kinase RIO1 [gi:56404949]
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50
[SID136935277]
Kd 0.024Binding constant for INSR kinase domain [AID624784, Type: Literature]Insulin receptor [gi:308153655]
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