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BioActivity Data for Compound CHEMBL3234543 (CID 57383401)

BioActivity Outcomes:
Active(8)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(8)
 
 
BioAssay Types:
Literature(7)
 
 
 
Confirmatory(3)
 
 
BioAssay Categories:
Biochemical(7)
 
 
 
Cell-based(7)
 
 
 
BioActivity Types:
AC50(3)
 
 
Potency(3)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 10    Data Row: 10   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID242621312]
AC50 0.07Antagonist activity at D2 receptor (unknown origin) expressed in Flp-In TREx 293 cells coexpressing chimeric Gqi5 protein assessed as calcium accumulation by Fluo-8AM dye based fluorescence analysis [AID1125899, Type: Literature]D(2) dopamine receptor [gi:118206]
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2
[SID242621312]
Ki 0.21Displacement of [3H]methylspiperone from human D2L receptor expressed in HEK cell membrane after 90 mins by scintillation counting analysis [AID1125902, Type: Literature]D(2) dopamine receptor [gi:118206]
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3
[SID242621312]
Ki 0.35Displacement of [3H]methylspiperone from human D3 receptor expressed in HEK293 cell membrane after 90 mins by scintillation counting analysis [AID1125903, Type: Literature]D(3) dopamine receptor [gi:1169206]
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4
[SID242621312]
AC50 0.363Antagonist activity at ProLink-tagged D2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of dopamine-stimulated beta-arrestin binding treated for 90 mins prior to dopamine challenge by PathHunter DiscoveRx assay [AID1125900, Type: Literature]D(2) dopamine receptor [gi:118206]
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5
[SID136889456]
Potency 0.363413HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: SAR in D2 Beta Arrestin Assay [AID624495, Type: confirmatory]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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6
[SID136889456]
Potency 4.44529HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: SAR in Primary Assay. [AID624496, Type: confirmatory]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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7
[SID242621312]
AC50 4.57Antagonist activity at ProLink-tagged D3 receptor (unknown origin) expressed in CHO cells assessed as inhibition of dopamine-stimulated beta-arrestin binding treated for 90 mins prior to dopamine challenge by PathHunter DiscoveRx assay [AID1125901, Type: Literature]D(3) dopamine receptor [gi:1169206]
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8
[SID136889456]
Potency 4.57509HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: SAR in D3 Beta Arrestin Assay [AID624500, Type: confirmatory]D(3) dopamine receptor [gi:1169206]
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9
[SID242621312]
Ratio of AC50 for ProLink-tagged D3 receptor (unknown origin) expressed in CHO cells to AC50 for ProLink-tagged D2 receptor (unknown origin) expressed in CHO cells by beta-arrestin assay [AID1125904, Type: Literature]
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10
[SID242621312]
Ratio of Ki for human D3 receptor expressed in HEK293 cell membrane to Ki for human D2L receptor expressed in HEK cell membrane [AID1125905, Type: Literature]
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