zolpidem (CID 5732) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(95)
 
 
Inactive(151)
 
 
Inconclusive(22)
 
 
Unspecified(149)
 
 
Top Targets:
Neur chan LBD(53)
 
 
 
p450(8)
 
 
 
HELICc(2)
 
 
Peptidase C1A(2)
 
 
PLN02808(2)
 
 
BioAssay Types:
Literature(317)
 
 
 
 
 
Confirmatory(75)
 
 
 
 
Screening(18)
 
 
BioActivity Types:
Ki(98)
 
 
 
Potency(73)
 
 
 
 
EC50(10)
 
 
 
IC50(6)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 356    Data Row: 417   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103238173]
IC50 0.014Inhibition of [3H]flumazenil binding to recombinant GABA-A receptor alpha-1 subunit in cerebellum [AID72469, Type: other]
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2
[SID103238173]
Ki 0.0155Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 M130C receptor mutant expressed in HEK293T cells [AID345429, Type: Literature]
View
3
[SID103238173]
Ki 0.019Binding affinity for rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells [AID219782, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
4
[SID103238173]
Ki 0.019Binding affinity for rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells [AID219782, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
5
[SID103238173]
Ki 0.019Binding affinity for rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells [AID219782, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
6
[SID103238173]
Ki 0.025Displacement of [3H]- flunitrazepam from rat GABA-A benzodiazepine receptor [AID40372, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
View
7
[SID103238173]
Ki 0.0267Displacement of [3H]Ro-151788 from rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells [AID72765, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
8
[SID103238173]
Ki 0.0267Displacement of [3H]Ro-151788 from rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells [AID72765, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
9
[SID103238173]
Ki 0.0267Displacement of [3H]Ro-151788 from rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells [AID72765, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
10
[SID103238173]
Ki 0.0267Binding affinity for recombinant rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells [AID72766, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
11
[SID103238173]
Ki 0.0267Binding affinity for recombinant rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells [AID72766, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
12
[SID103238173]
Ki 0.0267Binding affinity for recombinant rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells [AID72766, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
13
[SID103238173]
Ki 0.0267Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in HEK cells by liquid scintillation counting [AID527597, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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14
[SID103238173]
Ki 0.0267Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2 [AID72927, Type: Literature]
View
15
[SID103238173]
Ki 0.0267Binding affinity for rat alpha-1 beta2/3 gamma2 GABA A / BzR receptor [AID254367, Type: Literature]
View
16
[SID103238173]
Ki 0.0267Binding affinity measured using LtK- cell membranes expressing GABA alpha-1-beta-3-gamma-2 receptor [AID219791, Type: Literature]
View
17
[SID103238173]
Ki 0.027Binding affinity for human GABA-A receptor alpha-4-beta-3-gamma-2 subunits in L(tk-) cells [AID72467, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
18
[SID103238173]
Ki 0.027Displacement of [3H]Ro 15-1788 from human recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in L(tk-) cells [AID282665, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
19
[SID103238173]
Ki 0.027Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2 subtype expressed in L (tk-) cells [AID239564, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
20
[SID103238173]
Ki 0.035Displacement of [3H]flumazenil from rat GABA-A alpha-5-beta-3-gamma-2 receptor expressed in HEK293 cells [AID371920, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-5 [gi:120764]
View
21
[SID103238173]
Ki 0.0358Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 R132C receptor mutant expressed in HEK293T cells [AID345430, Type: Literature]
View
22
[SID103238173]
Ki 0.038Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 R144C receptor mutant expressed in HEK293T cells [AID345433, Type: Literature]
View
23
[SID103238173]
Ki 0.0412Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha1 S205C beta2gamma2 receptor mutant expressed in HEK293T cells [AID345445, Type: Literature]
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24
[SID103238173]
IC50 0.0463Inhibition of [3H]flumazenil binding to recombinant GABA-A receptor alpha-1-beta-2-gamma-2 subunits [AID72786, Type: other]
View
25
[SID103238173]
IC50 0.048Displacement of [3H]flunitrazepam from rat brain GABA-A Benzodiazepine receptor [AID42319, Type: Literature]
View
26
[SID103238173]
Ki 0.048Binding affinity was determined by displacement of [3H]flumazenil from rat cortex homogenates [AID187152, Type: Literature]
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27
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expressed in HEK293 cells [AID239648, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
28
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expressed in HEK293 cells [AID239648, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
29
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expressed in HEK293 cells [AID239648, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
30
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABAA alpha-1-beta-2-gamma-2 expressed in HEK293 cells [AID280841, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
31
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABAA alpha-1-beta-2-gamma-2 expressed in HEK293 cells [AID280841, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
32
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABAA alpha-1-beta-2-gamma-2 expressed in HEK293 cells [AID280841, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
33
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABA-Aalpha1 receptor plus beta-2-gamma-2 in HEK293 cells [AID262959, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
34
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABA-Aalpha1 receptor plus beta-2-gamma-2 in HEK293 cells [AID262959, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
35
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABA-Aalpha1 receptor plus beta-2-gamma-2 in HEK293 cells [AID262959, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
36
[SID103238173]
Ki 0.05Inhibition of [3H]flumazenil specific binding at rat GABA-A alpha-1-beta-2-gamma-2 receptor subunits expressed in HEK293 cells [AID72286, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
37
[SID103238173]
Ki 0.05Inhibition of [3H]flumazenil specific binding at rat GABA-A alpha-1-beta-2-gamma-2 receptor subunits expressed in HEK293 cells [AID72286, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
38
[SID103238173]
Ki 0.05Inhibition of [3H]flumazenil specific binding at rat GABA-A alpha-1-beta-2-gamma-2 receptor subunits expressed in HEK293 cells [AID72286, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
View
39
[SID103238173]
Ki 0.05Displacement of [3H]flumazenil from rat GABA-A alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cells [AID371917, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:51317298]
View
40
[SID103238173]
Ki 0.051Displacement of [3H]flumazenil from Benzodiazepine receptor in bovine cerebral cortex membrane [AID371915, Type: Literature]
View
41
[SID103238173]
Ki 0.0521Binding affinity towards human alpha-1-beta-3-gamma-2 GABA-A receptor using [3H]Ro-151788 expressed in L(tk-) cells [AID72916, Type: Literature]
View
42
[SID103238173]
Ki 0.053Displacement of [3H]Flumazenil from human GABA-Aalpha1 receptor plus beta-2-gamma-2 expressed in HEK293 cells [AID262560, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
View
43
[SID103238173]
Ki 0.053Displacement of [3H]Flumazenil from human GABA-Aalpha1 receptor plus beta-2-gamma-2 expressed in HEK293 cells [AID262560, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
View
44
[SID103238173]
Ki 0.0619Displacement of [3H]Ro15-1788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 receptor expressed in HEK293T cells [AID345418, Type: Literature]
View
45
[SID103238173]
Ki 0.0626Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 R194C receptor mutant expressed in HEK293T cells [AID345436, Type: Literature]
View
46
[SID103238173]
Ki 0.0631Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 L140C receptor mutant expressed in HEK293T cells [AID345431, Type: Literature]
View
47
[SID103238173]
Ki 0.0674Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 R185C receptor mutant expressed in HEK293T cells [AID345435, Type: Literature]
View
48
[SID103238173]
Ki 0.0676Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 D56C receptor mutant expressed in HEK293T cells [AID345424, Type: Literature]
View
49
[SID103238173]
Ki 0.0678Displacement of [3H]Ro15-1788 from benzodiazepine binding site of GABAA alpha-1 V211C beta2gamma2 receptor mutant expressed in HEK293T cells [AID345448, Type: Literature]
View
50
[SID103238173]
Ki 0.0727Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-1-beta-2-gamma-2 T126C receptor mutant expressed in HEK293T cells [AID345428, Type: Literature]
View