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zaleplon (CID 5719) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(380)
 
 
Inconclusive(19)
 
 
Unspecified(310)
 
 
Top Targets:
7TM GPCR Srx(25)
 
 
 
7TM GPCR Srsx(23)
 
 
 
NR LBD PPAR(14)
 
 
p450(10)
 
 
 
 
NR LBD ER(9)
 
 
 
BioAssay Types:
Confirmatory(314)
 
 
 
 
 
Literature(115)
 
 
 
 
 
Screening(101)
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(175)
 
 
 
IC50(144)
 
 
 
 
 
EC50(17)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 611    Data Row: 720   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103558703]
EC50 0.29Modulation of human GABA-A alpha1beta2gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726249, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
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2
[SID103558703]
EC50 0.29Modulation of human GABA-A alpha1beta2gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726249, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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3
[SID103558703]
EC50 0.29Modulation of human GABA-A alpha1beta2gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726249, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-2 [gi:292495010]
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4
[SID103558703]
IC50 0.412DRUGMATRIX: GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam) [AID625261, Type: confirmatory]
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5
[SID103558703]
EC50 1.63Modulation of human GABAA alpha2beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726248, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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6
[SID103558703]
EC50 1.63Modulation of human GABAA alpha2beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726248, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:126302547]
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7
[SID103558703]
EC50 1.63Modulation of human GABAA alpha2beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726248, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
View
8
[SID103558703]
GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator [AID742654, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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9
[SID103558703]
GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator [AID742654, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
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10
[SID103558703]
GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator [AID742654, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-1 [gi:23831128]
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11
[SID48416707]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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12
[SID103558703]
EC50 1Modulation of human GABAA alpha5beta3gamma3 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726251, Type: Literature]
View
13
[SID103558703]
EC50 1Modulation of human GABAA alpha3beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726247, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
View
14
[SID103558703]
EC50 1Modulation of human GABAA alpha3beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726247, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-3 [gi:462149]
View
15
[SID103558703]
EC50 1Modulation of human GABAA alpha3beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents [AID726247, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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16
[SID103558703]
Km 124Activity of aldehyde oxidase in human liver cytosol [AID547835, Type: Literature]Aldehyde oxidase [gi:215273968]
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17
[SID103558703]
Activity of aldehyde oxidase in human liver cytosol assessed as enzyme activity per mg of cytosol [AID547836, Type: Literature]Aldehyde oxidase [gi:215273968]
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18
[SID103558703]
IC50 DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: confirmatory]Kappa-type opioid receptor [gi:116242691]
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19
[SID103558703]
IC50 DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: confirmatory]Cytochrome P450 2D6 [gi:84028191]
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20
[SID103558703]
IC50 DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: confirmatory]Muscarinic acetylcholine receptor M4 [gi:23503039]
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