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7-hydroxy-3-(3-methoxyphenyl)-4H-chromen-4-one (CID 5715241) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(4)
 
 
Unspecified(17)
 
 
Top Targets:
NR LBD PPAR(11)
 
 
 
DUF3346(1)
 
 
G glu transpe..(1)
 
 
Sulfatase(1)
 
 
MarR(1)
 
 
BioAssay Types:
Literature(23)
 
 
 
BioActivity Types:
EC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 27    Data Row: 27   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103699214]
EC50 12.44Agonist activity at human PPARdelta expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736342, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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2
[SID103699214]
EC50 22.29Agonist activity at human PPARgamma expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736343, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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3
[SID103699214]
EC50 22.29Agonist activity at human PPARgamma assessed as luciferase activity by transactivation assay [AID439369, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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4
[SID103699214]
EC50 23.1Agonist activity at human PPARalpha assessed as luciferase activity by transactivation assay [AID439370, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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5
[SID103699214]
EC50 33.13Agonist activity at human PPARalpha expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736344, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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6
[SID103699214]
Reduction in Zucker diabetic fatty rat body weight gain at 3 mg/kg/day measured after 3 weeks [AID736338, Type: Literature]
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7
[SID103699214]
Cytotoxicity against human HEK293 cells assessed as cell viability at 100 uM measured after 48 hrs by MTS assay relative to vehicle control [AID736339, Type: Literature]
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8
[SID103699214]
Cytotoxicity against human HEK293 cells assessed as cell viability at 10 uM measured after 48 hrs by MTS assay relative to vehicle control [AID736340, Type: Literature]
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9
[SID103699214]
Agonist activity at human PPARgamma expressed in HEK293 cells co-transfected with PPRE assessed as beta-galactosidase signal at 5 uM after 48 hrs by reporter gene assay relative to control [AID439367, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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10
[SID103699214]
Agonist activity at human PPARgamma expressed in HEK293 cells co-transfected with PPRE assessed as beta-galactosidase signal at 25 uM after 48 hrs by reporter gene assay relative to control [AID439368, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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11
[SID103699214]
Cytotoxicity against HEK293 cells assessed as viable cells at 10 uM after 48 hrs by aqueous one solution cell proliferation assay relative to control [AID439373, Type: Literature]
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12
[SID103699214]
Cytotoxicity against HEK293 cells assessed as viable cells at 100 uM after 48 hrs by aqueous one solution cell proliferation assay relative to control [AID439374, Type: Literature]
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13
[SID103699214]
Cytotoxicity against HEK293 cells assessed as viable cells at 50 uM after 48 hrs by aqueous one solution cell proliferation assay relative to control [AID439376, Type: Literature]
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14
[SID103699214]
Antidiabetic activity against Zucker diabetic fatty rat assessed as blood glucose level at 3 mg/kg after 30 mins (Rvb = 270 mg/dL) [AID736332, Type: Literature]
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15
[SID103699214]
Antimetabolic syndrome activity in Zucker lean fatty rat assessed as inhibition of fatty liver disease in measured as liver mass at 3 mg/kg (Rvb = 8.6 g) [AID736333, Type: Literature]
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16
[SID103699214]
Antimetabolic syndrome activity in Zucker diabetic fatty rat assessed as inhibition of fatty liver disease in measured as liver mass at 3 mg/kg (Rvb = 23.9 g) [AID736334, Type: Literature]
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17
[SID103699214]
Antidiabetic activity against Zucker diabetic fatty rat assessed as blood glucose level at 3 mg/kg measured after 2 hrs of glucose intake by oral glucose tolerance test (Rvb = 185 mg/dL) [AID736335, Type: Literature]
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18
[SID103699214]
Antidiabetic activity against Zucker diabetic fatty rat assessed as blood glucose level at 3 mg/kg (Rvb = 124 mg/dL) [AID736336, Type: Literature]
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19
[SID103699214]
Reduction in Zucker diabetic fatty rat body weight gain at 3 mg/kg/day measured after 6 weeks (Rvb = 103 g) [AID736337, Type: Literature]
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20
[SID103699214]
Agonist activity at human PPARalpha expressed in HEK293 cells co-transfected with PPRE assessed as beta-galactosidase signal at 25 uM after 48 hrs by reporter gene assay relative to control [AID439371, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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