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Fenoterol (CID 5702161) - Compound BioActivity Data
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BioActivity Outcomes:
Active(25)
 
 
Inactive(816)
 
 
Inconclusive(59)
 
 
Unspecified(16)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
 
7TM GPCR Srsx(19)
 
 
 
 
HELICc(9)
 
 
G-alpha(9)
 
 
 
NR LBD TR(9)
 
 
BioAssay Types:
Screening(419)
 
 
 
 
Confirmatory(401)
 
 
 
 
 
Summary(25)
 
 
 
Literature(18)
 
 
 
 
BioActivity Types:
Potency(356)
 
 
 
 
 
IC50(39)
 
 
 
 
 
EC50(8)
 
 
 
AC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 761    Data Row: 916   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26732605]
IC50 0.000293969Dose responses of compounds that inhibit the Choline Transporter (CHT) - 10 point CRC [AID588401, Type: confirmatory]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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2
[SID26732605]
Potency 0.0411qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation [AID588463, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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3
[SID26732605]
EC50_MICROM 0.11Dose response for HTS for Beta-2AR agonists via FAP method from CP1 [AID588763, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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4
[SID26732605]
Potency 0.206qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation with GloSensor [AID588790, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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5
[SID26732605]
AC50_uM 3.81Control Cell Fusion Counterscreen Assay Measured in Cell-Based System Using Plate Reader - 7013-02_Inhibitor_Dose_CherryPick_Activity [AID652040, Type: confirmatory]
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6
[SID26732605]
AC50_uM 4.14HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
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7
[SID26732605]
AC50_uM 6.9HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_Dose_CherryPick_Activity [AID652057, Type: confirmatory]
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8
[SID26732605]
AC50_uM 7.68Cell fusion assay for clade C HIV-1ZM109 Env Measured in Cell-Based System Using Plate Reader - 7013-05_Inhibitor_Dose_CherryPick_Activity [AID652058, Type: confirmatory]
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9
[SID103676006]
EC50 8.2Agonist activity at adrenergic beta-2 receptor in guinea pig tracheal rings assessed as myorelaxing activity on carbachol-induced contraction [AID298207, Type: Literature]
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10
[SID26732605]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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11
[SID26732605]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
View
12
[SID26732605]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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13
[SID26732605]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
View
14
[SID26732605]
HTS for Beta-2AR agonists via FAP method, Single Point, Cherry Pick 1 [AID540358, Type: other]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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15
[SID26732605]
HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
View
16
[SID26732605]
Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
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17
[SID26732605]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4) [AID463165, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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18
[SID26732605]
Validation assay for identification of compounds that inhibit the regulator of G-protein signaling 4 (RGS4) [AID492999, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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19
[SID26732605]
Second counter screen for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4): Non-induced cells with the primary screen assay without carbachol activation [AID493001, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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20
[SID26732605]
Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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21
[SID26732605]
Confirmatory screen for compounds that inhibit the Choline Transporter (CHT) [AID493221, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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22
[SID26612148]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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23
[SID17405107]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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24
[SID26732605]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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25
[SID10321627]
MDR-1 [AID377, Type: other]multidrug resistance protein 1 [Homo sapiens] [gi:42741659]
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26
[SID103676006]
IC50 215Antioxidant activity in rat hepatic microsomal membrane [AID298204, Type: Literature]
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27
[SID8149694]
Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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28
[SID8149694]
Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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29
[SID8149694]
Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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30
[SID8149694]
Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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31
[SID8149694]
Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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32
[SID8149694]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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33
[SID8149694]
Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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34
[SID8149694]
Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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35
[SID8149694]
Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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36
[SID8149694]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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37
[SID103676006]
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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38
[SID103676006]
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
View
39
[SID103676006]
Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in Pfizer data [AID625295, Type: Literature]
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40
[SID26732605]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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41
[SID50106336]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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42
[SID26732605]
Potency 0.7079qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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43
[SID50106336]
Potency 0.8913qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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44
[SID26732605]
Potency 7.3753Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
45
[SID50106336]
Potency 23.7781qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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46
[SID26747517]
Potency 39.8107qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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47
[SID50106336]
Potency 44.6684qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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48
[SID26732605]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
View
49
[SID26732605]
uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]fatty acid synthase [Homo sapiens] [gi:41872631]
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50
[SID170465657]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743212, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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