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pirinixic acid (CID 5694) - Compound BioActivity Data
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BioActivity Outcomes:
Active(69)
 
 
Inactive(756)
 
 
Inconclusive(83)
 
 
Unspecified(1496)
 
 
Top Targets:
NR LBD PPAR(119)
 
 
 
 
 
NR LBD ER(27)
 
 
 
 
p450(26)
 
 
 
 
 
NR LBD TR(25)
 
 
 
NR LBD AR(25)
 
 
 
 
BioAssay Types:
Confirmatory(679)
 
 
 
 
 
Literature(208)
 
 
 
 
 
Screening(88)
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(502)
 
 
 
 
IC50(120)
 
 
 
 
EC50(49)
 
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1906    Data Row: 2404   Total Pages: 121   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103221520]
EC50 0.04Effective concentration against murine PPARalpha in transactivation assay [AID240162, Type: Literature]
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2
[SID103221520]
EC50 0.04Agonist activity at mouse PPARalpha ligand binding domain expressed in human Hep G2 cells co-transfected with Gal4-DBD by luciferase reporter gene assay [AID413011, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
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3
[SID103221520]
Ki 0.1Binding affinity towards peroxisome proliferator activated receptor alpha (murinePPAR alpha) [AID156230, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
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4
[SID103221520]
EC50 0.13Transactivation of human PPARalpha expressed in african green monkey CV1 cells by luciferase reporter gene assay [AID662543, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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5
[SID103221520]
EC50 0.542Agonist activity at human PPARalpha expressed in MCF7 cells co-transfected CPTI DR1-type RE after 6 hrs by luciferase reporter gene assay [AID660302, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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6
[SID103221520]
EC50 0.63Agonist activity for murine PPAR alpha receptor in transcriptional activation assay [AID141903, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
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7
[SID103221520]
EC50 0.65Agonist activity at human PPARalpha expressed in MCF7 cells co-transfected CPTI DR1-type RE after 16 hrs by luciferase reporter gene assay [AID660301, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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8
[SID103221520]
EC50 0.7Agonist activity at PPARalpha assessed as receptor transactivation by reporter gene assay [AID444227, Type: Literature]
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9
[SID103221520]
EC50 0.74Activation of human PPARalpha by GST pull down assay [AID275787, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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10
[SID103221520]
EC50 1.46In vitro transcription activation on human peroxisome proliferator activated receptor-delta (PPAR delta) [AID156234, Type: Literature]
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11
[SID103221520]
EC50 1.56Transactivation of GAL4-fused human PPARalpha ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene assay [AID722394, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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12
[SID103221520]
EC50 1.6Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648525, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
13
[SID103221520]
EC50 1.6Agonist activity at human GAL4-fused PPARalpha ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene transactivation assay [AID712381, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
14
[SID103221520]
EC50 1.6Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in human HepG2 cells assessed as receptor transactivation by luciferase reporter gene assay [AID440652, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
15
[SID103221520]
EC50 1.6Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay [AID344819, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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16
[SID103221520]
EC50 1.6Effective concentration against human PPARalpha expressed in HepG2 cells [AID240267, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
17
[SID103221520]
EC50 1.62Agonist activity at human PPARalpha ligand binding domain expressed in human Hep G2 cells co-transfected with Gal4-DBD by luciferase reporter gene assay [AID413009, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
18
[SID103221520]
EC50 2.1In vitro transactivation of rat Peroxisome proliferator activated receptor alpha [AID156459, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:585718]
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19
[SID103221520]
IC50 2.8169DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) [AID625208, Type: confirmatory]Aldose reductase [gi:1168407]
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20
[SID11114026]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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