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pirinixic acid (CID 5694) - Compound BioActivity Data
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BioActivity Outcomes:
Active(67)
 
 
Inactive(736)
 
 
Inconclusive(102)
 
 
Unspecified(1600)
 
 
Top Targets:
NR LBD PPAR(118)
 
 
 
 
 
NR LBD ER(27)
 
 
 
 
p450(26)
 
 
 
 
 
NR LBD TR(25)
 
 
 
NR LBD AR(25)
 
 
 
 
BioAssay Types:
Confirmatory(562)
 
 
 
 
 
Literature(204)
 
 
 
 
 
Screening(88)
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(501)
 
 
 
 
IC50(120)
 
 
 
 
EC50(47)
 
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2007    Data Row: 2505   Total Pages: 51   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103221520]
EC50 0.04Effective concentration against murine PPARalpha in transactivation assay [AID240162, Type: Literature]
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2
[SID103221520]
EC50 0.04Agonist activity at mouse PPARalpha ligand binding domain expressed in human Hep G2 cells co-transfected with Gal4-DBD by luciferase reporter gene assay [AID413011, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
View
3
[SID103221520]
Ki 0.1Binding affinity towards peroxisome proliferator activated receptor alpha (murinePPAR alpha) [AID156230, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
View
4
[SID103221520]
EC50 0.13Transactivation of human PPARalpha expressed in african green monkey CV1 cells by luciferase reporter gene assay [AID662543, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
5
[SID103221520]
EC50 0.542Agonist activity at human PPARalpha expressed in MCF7 cells co-transfected CPTI DR1-type RE after 6 hrs by luciferase reporter gene assay [AID660302, Type: other]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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6
[SID103221520]
EC50 0.63Agonist activity for murine PPAR alpha receptor in transcriptional activation assay [AID141903, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
View
7
[SID103221520]
EC50 0.65Agonist activity at human PPARalpha expressed in MCF7 cells co-transfected CPTI DR1-type RE after 16 hrs by luciferase reporter gene assay [AID660301, Type: other]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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8
[SID103221520]
EC50 0.7Agonist activity at PPARalpha assessed as receptor transactivation by reporter gene assay [AID444227, Type: Literature]
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9
[SID103221520]
EC50 0.74Activation of human PPARalpha by GST pull down assay [AID275787, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
10
[SID103221520]
EC50 1.46In vitro transcription activation on human peroxisome proliferator activated receptor-delta (PPAR delta) [AID156234, Type: Literature]
View
11
[SID103221520]
EC50 1.56Transactivation of GAL4-fused human PPARalpha ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene assay [AID722394, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
12
[SID103221520]
EC50 1.6Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in human HepG2 cells assessed as receptor transactivation by luciferase reporter gene assay [AID440652, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
13
[SID103221520]
EC50 1.6Effective concentration against human PPARalpha expressed in HepG2 cells [AID240267, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
14
[SID103221520]
EC50 1.6Agonist activity at human GAL4-fused PPARalpha ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene transactivation assay [AID712381, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
15
[SID103221520]
EC50 1.6Agonist activity at human PPARgamma ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay [AID344819, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
16
[SID103221520]
EC50 1.6Agonist activity at GAL4-tagged human PPARalpha ligand binding domain expressed in HepG2 cells assessed as transactivation after 20 hrs by beta-galactosidase reporter gene assay [AID648525, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
17
[SID103221520]
EC50 1.62Agonist activity at human PPARalpha ligand binding domain expressed in human Hep G2 cells co-transfected with Gal4-DBD by luciferase reporter gene assay [AID413009, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
18
[SID103221520]
EC50 2.1In vitro transactivation of rat Peroxisome proliferator activated receptor alpha [AID156459, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:585718]
View
19
[SID103221520]
IC50 2.8169DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) [AID625208, Type: other]Aldose reductase [gi:1168407]
View
20
[SID11114026]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
View
21
[SID103221520]
EC50 4.8Transactivation of human PPARalpha expressed in human HepG2 cells co-transfected with PPRE3-TK-Luc by luciferase reporter gene assay [AID610309, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
22
[SID103221520]
EC50 4.8Agonist activity at PPARalpha expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assay relative to control [AID365528, Type: Literature]
View
23
[SID103221520]
EC50 5Agonist activity for Human PPAR alpha receptor in transcriptional activation assay [AID91237, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
24
[SID11114026]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
25
[SID144208807]
Ratio Potency (uM) 8.7033qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
26
[SID144210951]
Ratio Potency (uM) 9.33987qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
27
[SID144203609]
Ratio Potency (uM) 9.52052qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
28
[SID11114026]
Potency 10qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
29
[SID103221520]
IC50 10.11Binding affinity to GST-tagged human PPARalpha by TR-FRET analysis [AID662549, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
30
[SID103221520]
EC50 12Agonist activity at human PPARalpha in U2OS cells by transactivation assay [AID396052, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
31
[SID103221520]
EC50 12.6In vitro transactivation of human Peroxisome proliferator activated receptor alpha (hPPARalpha) [AID156146, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
32
[SID103221520]
EC50 12.6In vitro transactivation using receptor transactivation assay against hPPAR alpha [AID223541, Type: Literature]
View
33
[SID103221520]
EC50 13Effective concentration for human peroxisome proliferator-activated receptor alpha [AID240119, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
34
[SID103221520]
EC50 13Agonist activity at human PPARalpha by transactivation assay [AID307130, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
35
[SID103221520]
EC50 15.5In vitro transcription activation on human peroxisome proliferator activated receptor-alpha (PPAR alpha) [AID156218, Type: Literature]
View
36
[SID103221520]
EC50 20Effect on PPARalpha transactivation activity in U2OS cells [AID260994, Type: Literature]
View
37
[SID103221520]
EC50 23.33Agonist activity at human PPARalpha expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay [AID736344, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
38
[SID103221520]
EC50 23.33Agonist activity at human PPARalpha assessed as luciferase activity by transactivation assay [AID439370, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
39
[SID11114026]
Potency 25.1189qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
View
40
[SID103221520]
EC50 29Agonist activity at human PPARgamma by transactivation assay [AID307132, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
41
[SID103221520]
EC50 29Effective concentration for human peroxisome proliferator-activated receptor gamma [AID240121, Type: Literature]
View
42
[SID103221520]
EC50 29.3In vitro transactivation using receptor transactivation assay against hPPAR gamma [AID223547, Type: Literature]
View
43
[SID103221520]
EC50 29.3In vitro transactivation of human Peroxisome proliferator activated receptor gamma [AID156943, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
44
[SID103221520]
EC50 32Agonist activity for murine PPAR gamma receptor in transcriptional activation assay [AID141913, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
View
45
[SID103221520]
EC50 35Agonist activity for Human PPAR delta receptor in transcriptional activation assay [AID91241, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
46
[SID103221520]
Transactivation of mouse recombinant PPARalpha expressed in mouse NIH3T3 cells at 0.1 uM to 10 uM by PPRE activation based dual luciferase reporter gene assay relative to control [AID416165, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:1709728]
View
47
[SID103221520]
Agonist activity at human PPARalpha expressed in MCF7 cells transfected with co-activator TIF2 by luciferase reporter gene assay at 1 uM [AID275788, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
48
[SID103221520]
Agonist activity at PPARalpha in human HepG2 cells assessed as upregulation of CPT1 mRNA expression at 50 uM after 24 hrs by RT-PCR analysis relative to control [AID722379, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
49
[SID103221520]
Agonist activity at PPARalpha in human HepG2 cells assessed as upregulation of CAC mRNA expression at 50 uM after 24 hrs by RT-PCR analysis relative to control [AID722380, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View
50
[SID103221520]
Binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR alpha) by HTRF assay; Weakly active [AID156221, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
View