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CHEMBL1923638 (CID 56926894) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inconclusive(4)
 
 
Unspecified(3)
 
 
Top Targets:
Motilin assoc(2)
 
 
BioAssay Types:
Literature(9)
 
 
 
 
BioActivity Types:
EC50(1)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 9   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136927986]
EC50 0.026Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay [AID632806, Type: Literature]Appetite-regulating hormone [gi:17865471]
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2
[SID136927986]
Ki 0.056Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay [AID632805, Type: Literature]Appetite-regulating hormone [gi:17865471]
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3
[SID136927986]
Elimination half life in Sprague-Dawley rat at 2 m/kg, iv [AID632810, Type: Literature]
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4
[SID136927986]
Volume of distribution at steady state in Sprague-Dawley rat at 2 m/kg, iv [AID632811, Type: Literature]
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5
[SID136927986]
Clearance in Sprague-Dawley rat at 2 m/kg, iv [AID632812, Type: Literature]
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6
[SID136927986]
Oral bioavailability in Sprague-Dawley rat at 2 mg/kg [AID632813, Type: Literature]
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7
[SID136927986]
Induction of gastric emptying in overnight-fasted iv dosed Wistar rat measured after 15 mins by calorimetric analysis [AID632989, Type: Literature]
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8
[SID136927986]
Cmax in Sprague-Dawley rat at 8 mg/kg, po [AID632808, Type: Literature]
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9
[SID136927986]
AUC (0 to infinity) in Sprague-Dawley rat at 8 mg/kg, po [AID632809, Type: Literature]
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