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CHEMBL1940617 (CID 56926077) - Compound BioActivity Data
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BioActivity Outcomes:
Inactive(1)
 
 
Inconclusive(1)
 
 
Unspecified(3)
 
 
Top Targets:
Esterase lipa..(3)
 
 
 
BioAssay Types:
Literature(5)
 
 
 
 
BioActivity Types:
IC50(2)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 5    Data Row: 5   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136945341]
IC50 64.5Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate after 20 mins preincubation by Ellman method [AID642369, Type: Literature]Acetylcholinesterase [gi:113037]
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2
[SID136945341]
IC50 294Inhibition of human recombinant BuChE using butyrylthiocholine iodide as substrate after 20 mins preincubation by Ellman method [AID642370, Type: Literature]Cholinesterase [gi:116353]
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3
[SID136945341]
Inhibition of amyloid beta (1 to 42) self-aggregation assessed as fibril formation at 10 uM after 24 hrs by thioflavin T-based fluorometric assay [AID642374, Type: Literature]
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4
[SID136945341]
Inhibition of recombinant BACE1 expressed in baculovirus system using panvera peptide as substrate at 3 uM after 60 mins by spectrofluorometric analysis [AID642371, Type: Literature]
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5
[SID136945341]
Inhibition of human recombinant AChE-induced amyloid beta 40 aggregation assessed as fibril formation at 100 uM after 24 hrs by thioflavin T-based fluorometric assay [AID642373, Type: Literature]Acetylcholinesterase [gi:113037]
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