CHEMBL1958349 (CID 56924662) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Unspecified(4)
 
 
Top Targets:
prostaglandin..(2)
 
 
BioAssay Types:
Literature(6)
 
 
 
BioActivity Types:
IC50(2)
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 6    Data Row: 6   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136940759]
IC50 0.0002Inhibition of human recombinant COX2 [AID648862, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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2
[SID136940759]
IC50 6.44Inhibition of ovine COX1 [AID648861, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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3
[SID136940759]
 Lipophilicity, log P of the compound [AID648869, Type: Literature]
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4
[SID136940759]
 Ulcerogenic effect in rat assessed as gastric ulcer overall length at 1.4 mmol/kg, po administered for 6 hrs [AID648871, Type: Literature]
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5
[SID136940759]
 Selectivity ratio of IC50 for ovine COX1 to IC50 for human recombinant COX2 [AID648873, Type: Literature]
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6
[SID136940759]
 Antiinflammatory activity in rat assessed as inhibition of carrageenan-induced paw edema at 0.32 mmol/kg, po after 3 hrs relative to control [AID648866, Type: Literature]
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