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CHEMBL2180730 (CID 56923423) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(1)
 
 
Inconclusive(1)
 
 
Unspecified(3)
 
 
Top Targets:
PTZ00435(3)
 
 
 
BioAssay Types:
Confirmatory(11)
 
 
 
 
 
BioActivity Types:
IC50(5)
 
 
Potency(4)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 12    Data Row: 12   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID163328551]
IC50 0.03Inhibition of IDH1 R132C mutant using alpha-ketoglutarate as substrate after 60 mins by resazurin-based fluorimetric analysis [AID704651, Type: confirmatory]
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2
[SID135542737]
Potency 0.044qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): confirmation assay for probe SAR [AID624023, Type: confirmatory]isocitrate dehydrogenase 1, partial [Homo sapiens] [gi:89573979]
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3
[SID163328551]
IC50 0.05Inhibition of IDH1 R132H mutant using alpha-ketoglutarate as substrate after 60 mins by resazurin-based fluorimetric analysis [AID704657, Type: confirmatory]
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4
[SID163328551]
IC50 0.15Inhibition of IDH1 R132C mutant overexpressed in human HT1080 cells assessed as inhibition of 2-hydroxyglutarate production after 48 hrs by LC/MS analysis [AID704650, Type: confirmatory]
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5
[SID163328551]
IC50 0.19Inhibition of IDH1 R132H mutant expressed in human U87 cells assessed as inhibition of 2-hydroxyglutarate production after 48 hrs by LC/MS analysis [AID704653, Type: confirmatory]
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6
[SID135542737]
Potency 1.21qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): 2HG production assay for probe SAR [AID624019, Type: confirmatory]isocitrate dehydrogenase 1, partial [Homo sapiens] [gi:89573979]
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7
[SID163328551]
IC50 2.9Inhibition of wild type IDH1 using DL-isocitrate as substrate by resazurin-based fluorimetric analysis [AID704648, Type: confirmatory]
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8
[SID163328551]
GI50 20Growth inhibition of human HT1080 cells after 72 hrs by CellTiter-Glo assay [AID704649, Type: confirmatory]
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9
[SID163328551]
GI50 20Growth inhibition of human U87 cells after 72 hrs by CellTiter-Glo assay [AID704652, Type: confirmatory]
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10
[SID163328551]
Inhibition of wild type IDH1 using DL-isocitrate as substrate by resazurin-based fluorimetric analysis relative to control [AID704647, Type: other]
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11
[SID135542737]
Potency qHTS for Inhibitors of Mutant Isocitrate Dehydrogenase 1 (IDH1): U87 Cytotoxicity Assay for Probe SAR [AID624059, Type: confirmatory]
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12
[SID135542737]
Potency 2.976qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): WT assay for probe SAR [AID624021, Type: confirmatory]isocitrate dehydrogenase 1, partial [Homo sapiens] [gi:89573979]
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