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SMR000152830 (CID 5689963) - Compound BioActivity Data
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BioActivity Outcomes:
Active(105)
 
 
Inactive(639)
 
 
Inconclusive(40)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
7TM GPCR Srsx(19)
 
 
Bcl-2 like(14)
 
 
 
alkPPc(14)
 
 
 
Troponin(8)
 
 
 
BioAssay Types:
Screening(525)
 
 
 
 
 
Confirmatory(232)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(155)
 
 
 
 
 
IC50(56)
 
 
 
 
EC50(12)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 708    Data Row: 787   Total Pages: 40   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17385711]
IC50 0.49262High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 isoform 1 [Homo sapiens] [gi:27894344]
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2
[SID17385711]
AC50_uM 0.665Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity [AID1053173, Type: confirmatory]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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3
[SID89850354]
Potency 0.7079qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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4
[SID17385711]
Potency 0.8913qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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5
[SID89850354]
Potency 0.919qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:115503961]
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6
[SID89850354]
Potency 0.9614qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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7
[SID17385711]
AbsAC35_uM 0.993ALPHAscreen artifact counterscreen Measured in Biochemical System Using Plate Reader - 7053-03_Inhibitor_Dose_CherryPick_Activity [AID1053174, Type: confirmatory]
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8
[SID89850354]
Potency 1.0691qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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9
[SID89850354]
Potency 1.122qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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10
[SID89850354]
Potency 1.122qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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11
[SID17385711]
Potency 1.5101Inhibitors of T. brucei phosphofructokinase: Hit Validation [AID504637, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:72386991]
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12
[SID17385711]
Potency 1.6944Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation [AID504636, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:72386991]
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13
[SID17385711]
Potency 1.7783qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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14
[SID17385711]
Potency 1.9953qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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15
[SID89850354]
Potency 2.3778qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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16
[SID89850354]
Potency 2.4149qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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17
[SID17385711]
DR_IC50 2.6LYP Inhibitors - Confirmatory Screen [AID1253, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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18
[SID89850354]
IC50 2.647Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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19
[SID89850354]
IC50 2.647Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]troponin I, cardiac muscle [Homo sapiens] [gi:151101270]
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20
[SID89850354]
IC50 2.647Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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