CHEMBL1921839 (CID 56851423) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(3)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(6)
 
 
 
BioAssay Types:
Literature(13)
 
 
 
 
BioActivity Types:
Ki(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 13    Data Row: 13   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136931596]
Ki 0.00921Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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2
[SID136931596]
Ki 0.00921Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
3
[SID136931596]
Ki 0.00921Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
4
[SID136931596]
Ki 0.00921Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
5
[SID136931596]
Ki 0.232Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
6
[SID136931596]
Ki 0.232Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
7
[SID136931596]
Ki 0.232Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
8
[SID136931596]
Ki 0.232Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
9
[SID136931596]
 Antagonist activity at human opioid mu receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631365, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
10
[SID136931596]
 Antagonist activity at human opioid mu receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631365, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
11
[SID136931596]
 Antagonist activity at human opioid mu receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631365, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
12
[SID136931596]
 Antagonist activity at human opioid mu receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631365, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
13
[SID136931596]
 Antagonist activity at human opioid delta receptor expressed in HEK293 cells assessed as inhibition of DPDPE-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631347, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
14
[SID136931596]
 Antagonist activity at human opioid delta receptor expressed in HEK293 cells assessed as inhibition of DPDPE-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631347, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
15
[SID136931596]
 Antagonist activity at human opioid kappa receptor expressed in CHO cells assessed as inhibition of U69593-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631364, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
16
[SID136931596]
 Antagonist activity at human opioid kappa receptor expressed in CHO cells assessed as inhibition of U69593-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631364, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
17
[SID136931596]
 Antagonist activity at human opioid kappa receptor expressed in CHO cells assessed as inhibition of U69593-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631364, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
18
[SID136931596]
 Antagonist activity at human opioid kappa receptor expressed in CHO cells assessed as inhibition of U69593-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631364, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
19
[SID136931596]
Ki 0.5Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting [AID631361, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
20
[SID136931596]
Ki 0.5Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting [AID631361, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
21
[SID136931596]
 Selectivity ratio of Ki for human opioid mu receptor expressed in CHO cells to Ki for human opioid kappa receptor expressed in CHO cells [AID631362, Type: Literature]
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22
[SID136931596]
 Selectivity ratio of Ki for human opioid delta receptor expressed in HEK293 cells to Ki for human opioid kappa receptor expressed in CHO cells [AID631363, Type: Literature]
View
23
[SID136931596]
 Selectivity ratio of Kb for human opioid delta receptor expressed in HEK293 cells to Kb for human opioid kappa receptor expressed in CHO cells [AID631391, Type: Literature]
View
24
[SID136931596]
 Selectivity ratio of Kb for human opioid mu receptor expressed in CHO cells to Kb for human opioid kappa receptor expressed in CHO cells [AID631348, Type: Literature]
View
25
[SID136931596]
 Agonist activity at human opioid delta receptor expressed in HEK293 cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631394, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
26
[SID136931596]
 Agonist activity at human opioid delta receptor expressed in HEK293 cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631394, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
27
[SID136931596]
 Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631392, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
28
[SID136931596]
 Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631392, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
29
[SID136931596]
 Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631392, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
30
[SID136931596]
 Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631392, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
31
[SID136931596]
 Agonist activity at human opioid mu receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631393, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
32
[SID136931596]
 Agonist activity at human opioid mu receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631393, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
33
[SID136931596]
 Agonist activity at human opioid mu receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631393, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
34
[SID136931596]
 Agonist activity at human opioid mu receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631393, Type: Literature]Mu-type opioid receptor [gi:2851402]
View