Bookmark and Share
CHEMBL1923502 (CID 56841653) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(1)
 
 
Unspecified(23)
 
 
Top Targets:
p450(5)
 
 
 
Motilin assoc(2)
 
 
CAP ED(1)
 
 
BioAssay Types:
Literature(29)
 
 
 
 
BioActivity Types:
IC50(5)
 
 
 
EC50(1)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 29    Data Row: 29   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136937982]
Ki 0.016Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay [AID632805, Type: Literature]Appetite-regulating hormone [gi:17865471]
View
2
[SID136937982]
EC50 0.029Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay [AID632806, Type: Literature]Appetite-regulating hormone [gi:17865471]
View
3
[SID136937982]
IC50 2.4Inhibition of human CYP3A4 [AID632818, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
View
4
[SID136937982]
Cmax in Sprague-Dawley rat at 8 mg/kg, po [AID632808, Type: Literature]
View
5
[SID136937982]
Cmax in cynomolgus monkey at 8 mg/kg, po [AID632825, Type: Literature]
View
6
[SID136937982]
IC50 66Inhibition of human CYP2C9 [AID632820, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
View
7
[SID136937982]
IC50 84Inhibition of human CYP2D6 [AID632819, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
View
8
[SID136937982]
IC50 100Inhibition of human CYP2C19 [AID632821, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
View
9
[SID136937982]
IC50 100Inhibition of human CYP1A2 [AID632822, Type: Literature]Cytochrome P450 1A2 [gi:117144]
View
10
[SID136937982]
Fraction unbound in rat plasma [AID632823, Type: Literature]
View
11
[SID136937982]
Drug excretion in Sprague-Dawley rat assessed as unchanged recovery in feces at 6 mg/kg, po measured after 30 mins [AID632824, Type: Literature]
View
12
[SID136937982]
Dissociation constant, pKa of the compound [AID632987, Type: Literature]
View
13
[SID136937982]
Induction of gastric emptying in overnight-fasted iv dosed Wistar rat measured after 15 mins by calorimetric analysis [AID632989, Type: Literature]
View
14
[SID136937982]
AUC (0 to infinity) in cynomolgus monkey at 8 mg/kg, po [AID632826, Type: Literature]
View
15
[SID136937982]
Elimination half life in cynomolgus monkey at 2 mg/kg, iv [AID632981, Type: Literature]
View
16
[SID136937982]
Volume of distribution at steady state in cynomolgus monkey at 2 mg/kg, iv [AID632982, Type: Literature]
View
17
[SID136937982]
Clearance in cynomolgus monkey at 2 mg/kg, iv [AID632983, Type: Literature]
View
18
[SID136937982]
Oral bioavailability in cynomolgus monkey at 8 mg/kg [AID632984, Type: Literature]
View
19
[SID136937982]
Induction of mutagenicity in Salmonella Typhimurium up to 5000 ug/plate by Ames test [AID632985, Type: Literature]
View
20
[SID136937982]
AUC (0 to infinity) in Sprague-Dawley rat at 8 mg/kg, po [AID632809, Type: Literature]
View