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CHEMBL1957971 (CID 56838295) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Unspecified(2)
 
 
Top Targets:
Lipoxygenase(4)
 
 
 
HAD like(1)
 
 
BioAssay Types:
Literature(5)
 
 
 
BioActivity Types:
IC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 5    Data Row: 5   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136936034]
IC50 0.059Inhibition of human recombinant soluble epoxide hydrolase expressed in Escherichia coli using 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methylester-2-oxiraneacetic acid as substrate after 30 mins by fluorescence-based assay [AID736008, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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2
[SID136936034]
IC50 0.1Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID650763, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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3
[SID136936034]
IC50 0.16Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis [AID650762, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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4
[SID136936034]
IC50 10Inhibition of human recombinant 5-LO expressed in Escherichia coli after 15 mins by HPLC analysis [AID736007, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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5
[SID136936034]
Ratio of zileuton IC50 to compound IC50 for human 5-lipoxygenase [AID650764, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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