Bookmark and Share
AC1NWD3L (CID 5680788) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(174)
 
 
Inactive(454)
 
 
Inconclusive(39)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
7TM GPCR Srsx(14)
 
 
 
KCNQ channel(9)
 
 
 
G-alpha(8)
 
 
 
Bcl-2 like(8)
 
 
BioAssay Types:
Screening(416)
 
 
 
 
Confirmatory(233)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(55)
 
 
 
EC50(19)
 
 
 
 
AC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 610    Data Row: 668   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24837215]
EC50_uM 0.123Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
View
2
[SID24837215]
AC50_uM 0.1278Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
View
3
[SID24837215]
AC50_uM 0.1792Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
View
4
[SID24837215]
EC50_uM 0.1915Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
View
5
[SID24837215]
EC50 0.236Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
View
6
[SID24837215]
IC50 0.42789Luminescence-based dose response cell-based high throughput screening assay for cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1972, Type: confirmatory]
View
7
[SID24837215]
Potency 0.4654Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
8
[SID24837215]
EC50 0.486Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
View
9
[SID24837215]
EC50 0.55Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
View
10
[SID24837215]
Potency 0.6513qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
11
[SID24837215]
IC50 0.6564Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1913, Type: confirmatory]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
12
[SID24837215]
IC50 0.69764Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID743297, Type: confirmatory]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
View
13
[SID24837215]
IC50 0.702HTS Counterscreen for Detection of Compound Cytotoxicity in MIN6 Cells [AID2122, Type: confirmatory]
View
14
[SID24837215]
AC50_uM 0.883MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
View
15
[SID24837215]
IC50 0.975HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells [AID1628, Type: confirmatory]
View
16
[SID24837215]
Potency 1qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
17
[SID24837215]
Potency 1.0323qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter [AID720537, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
18
[SID24837215]
Potency 1.0323qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
View
19
[SID24837215]
Potency 1.122qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
View
20
[SID24837215]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
21
[SID24837215]
Absolute IC50 (CHOP) 1.19CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
View
22
[SID24837215]
Absolute IC50 (XBP1) 1.21XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
View
23
[SID24837215]
Potency 1.4581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
24
[SID24837215]
Potency 1.4581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
View
25
[SID24837215]
IC50 1.648Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1692, Type: confirmatory]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
View
26
[SID24837215]
EC50 1.681Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
View
27
[SID24837215]
EC50 1.969Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
View
28
[SID24837215]
Potency 1.9953qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
View
29
[SID24837215]
Potency 2.3109qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
30
[SID24837215]
Potency 2.5119qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
View
31
[SID24837215]
Potency 2.5119qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
View
32
[SID24837215]
CC50 2.586Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - HeLa Cytotoxicity [AID624300, Type: confirmatory]
View
33
[SID24837215]
IC50 2.69Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
View
34
[SID24837215]
Potency 3.5481qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
35
[SID24837215]
Potency 3.5481qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
View
36
[SID24837215]
Potency 3.6626qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
37
[SID24837215]
IC50 4.232Fluorescence-based counterscreen assay for S1P4 antagonists: Cell-based dose response high throughput screening assay to identify antagonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1) [AID1821, Type: confirmatory]sphingosine 1-phosphate receptor 1 [Homo sapiens] [gi:13027636]
View
38
[SID24837215]
Potency 4.4668Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
View
39
[SID24837215]
Potency 5.1735A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
View
40
[SID24837215]
IC50 5.18uHTS fluorescence for the identification of compounds that decrease EGFP protein stability [AID2005, Type: confirmatory]
View
41
[SID24837215]
EC50 5.589Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
View
42
[SID24837215]
IC50_Mean 6.28Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) in the hexokinase 1 selectivity assay [AID504763, Type: confirmatory]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
View
43
[SID24837215]
Potency 6.3096qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
View
44
[SID24837215]
Potency 6.3096qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
View
45
[SID24837215]
Potency 6.5104qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
View
46
[SID24837215]
EC50 7.103Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
View
47
[SID24837215]
Potency 7.9433qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
View
48
[SID24837215]
IC50_Mean 8.31Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) [AID504729, Type: confirmatory]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
View
49
[SID24837215]
Potency 8.9125qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
View
50
[SID24837215]
Potency 11.2202qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View