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AC1NWD3L (CID 5680788) - Compound BioActivity Data
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BioActivity Outcomes:
Active(177)
 
 
Inactive(463)
 
 
Inconclusive(39)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
7TM GPCR Srsx(14)
 
 
 
KCNQ channel(9)
 
 
 
Bcl-2 like(8)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(422)
 
 
 
 
Confirmatory(233)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(55)
 
 
 
EC50(19)
 
 
 
 
AC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 614    Data Row: 680   Total Pages: 34   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24837215]
EC50_uM 0.123Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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2
[SID24837215]
AC50_uM 0.1278Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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3
[SID24837215]
AC50_uM 0.1792Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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4
[SID24837215]
EC50_uM 0.1915Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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5
[SID24837215]
EC50 0.236Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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6
[SID24837215]
IC50 0.42789Luminescence-based dose response cell-based high throughput screening assay for cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1972, Type: confirmatory]
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7
[SID24837215]
Potency 0.4654Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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8
[SID24837215]
EC50 0.486Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
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9
[SID24837215]
EC50 0.55Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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10
[SID24837215]
Potency 0.6513qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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11
[SID24837215]
IC50 0.6564Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1913, Type: confirmatory]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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12
[SID24837215]
IC50 0.69764Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID743297, Type: confirmatory]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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13
[SID24837215]
IC50 0.702HTS Counterscreen for Detection of Compound Cytotoxicity in MIN6 Cells [AID2122, Type: confirmatory]
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14
[SID24837215]
AC50_uM 0.883MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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15
[SID24837215]
IC50 0.975HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells [AID1628, Type: confirmatory]
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16
[SID24837215]
Potency 1qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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17
[SID24837215]
Potency 1.0323qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter [AID720537, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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18
[SID24837215]
Potency 1.0323qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
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19
[SID24837215]
Potency 1.122qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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20
[SID24837215]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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