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CHEMBL1808384 (CID 56673522) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(3)
 
 
p450(1)
 
 
BioAssay Types:
Literature(16)
 
 
 
BioActivity Types:
Ki(9)
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 16    Data Row: 16   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134452400]
Ki 0.0035Antagonist activity at human mu opioid receptor by GTP-gamma S binding assay [AID649256, Type: Literature]Mu-type opioid receptor [gi:2851402]
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2
[SID134452400]
Ki 0.0041Displacement of [3H]DAMGO from mu opioid receptor in dog brain after 90 mins by scintillation counting [AID649261, Type: Literature]
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3
[SID134452400]
Ki 0.0041Binding affinity to dog mu opioid receptor [AID609729, Type: Literature]
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4
[SID134452400]
Ki 0.00479Displacement of [3H]DAMGO from human mu opioid receptor [AID609728, Type: Literature]Mu-type opioid receptor [gi:2851402]
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5
[SID134452400]
Ki 0.0048Displacement of [3H]DAMGO from human mu opioid receptor [AID649258, Type: Literature]Mu-type opioid receptor [gi:2851402]
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6
[SID134452400]
Kd 0.01072Antagonist activity at mu opioid receptor in guinea pig longitudinal muscle myenteric plexus assessed as inhibition of DAMGO-induced twitch tension at 1 uM after 10 mins [AID649257, Type: Literature]Mu-type opioid receptor [gi:3024265]
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7
[SID134452400]
Kd 0.01072Antagonist activity at mu opioid receptor in guinea pig longitudinal muscle myenteric plexus assessed as inhibition of DAMGO-induced contraction after 10 mins [AID609732, Type: Literature]Mu-type opioid receptor [gi:3024265]
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8
[SID134452400]
Ki 0.094Binding affinity to dog kappa opioid receptor [AID609730, Type: Literature]
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9
[SID134452400]
Ki 0.094Displacement of [3H]U-69,593 from kappa opioid receptor in dog brain after 90 mins by scintillation counting [AID649260, Type: Literature]
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10
[SID134452400]
Ki 0.183Displacement of [3H]DPDPE from delta opioid receptor in dog brain after 90 mins by scintillation counting [AID649259, Type: Literature]
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11
[SID134452400]
Ki 0.183Binding affinity to dog delta opioid receptor [AID609731, Type: Literature]
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12
[SID134452400]
Antipruritic activity in dog with flea allergy dermatitis at 2 mg/kg, po upto 12 hrs [AID609736, Type: Literature]
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13
[SID134452400]
Inhibition of dog CYP2D15 [AID609737, Type: Literature]Cytochrome P450 2D15 [gi:2493366]
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14
[SID134452400]
Inhibition of morphine-induced antinociception in ICR mouse assessed as antagonism of morphine response to heat-induced tail flick at 10 mg/kg, sc preincubated for 15 mins before the addition of morphine assessed after 30 mins [AID609733, Type: Literature]
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15
[SID134452400]
Genotoxicity in Salmonella Typhimurium by Ames test [AID609734, Type: Literature]
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16
[SID134452400]
Genotoxicity in CHO cells by micronucleus assay [AID609735, Type: Literature]
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