CHEMBL1808384 (CID 56673522) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(13)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(3)
 
 
p450(1)
 
 
BioAssay Types:
Literature(16)
 
 
 
BioActivity Types:
Ki(9)
 
 
Kd(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 16    Data Row: 16   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134452400]
Ki 0.0035Antagonist activity at human mu opioid receptor by GTP-gamma S binding assay [AID649256, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
2
[SID134452400]
Ki 0.0035Antagonist activity at human mu opioid receptor by GTP-gamma S binding assay [AID649256, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
3
[SID134452400]
Ki 0.0035Antagonist activity at human mu opioid receptor by GTP-gamma S binding assay [AID649256, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
4
[SID134452400]
Ki 0.0035Antagonist activity at human mu opioid receptor by GTP-gamma S binding assay [AID649256, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
5
[SID134452400]
Ki 0.0041Binding affinity to dog mu opioid receptor [AID609729, Type: Literature]
View
6
[SID134452400]
Ki 0.0041Displacement of [3H]DAMGO from mu opioid receptor in dog brain after 90 mins by scintillation counting [AID649261, Type: Literature]
View
7
[SID134452400]
Ki 0.00479Displacement of [3H]DAMGO from human mu opioid receptor [AID609728, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
8
[SID134452400]
Ki 0.00479Displacement of [3H]DAMGO from human mu opioid receptor [AID609728, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
9
[SID134452400]
Ki 0.00479Displacement of [3H]DAMGO from human mu opioid receptor [AID609728, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
10
[SID134452400]
Ki 0.00479Displacement of [3H]DAMGO from human mu opioid receptor [AID609728, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
11
[SID134452400]
Ki 0.0048Displacement of [3H]DAMGO from human mu opioid receptor [AID649258, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
12
[SID134452400]
Ki 0.0048Displacement of [3H]DAMGO from human mu opioid receptor [AID649258, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
13
[SID134452400]
Ki 0.0048Displacement of [3H]DAMGO from human mu opioid receptor [AID649258, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
14
[SID134452400]
Ki 0.0048Displacement of [3H]DAMGO from human mu opioid receptor [AID649258, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
15
[SID134452400]
Kd 0.01072Antagonist activity at mu opioid receptor in guinea pig longitudinal muscle myenteric plexus assessed as inhibition of DAMGO-induced twitch tension at 1 uM after 10 mins [AID649257, Type: Literature]Mu-type opioid receptor [gi:3024265]
View
16
[SID134452400]
Kd 0.01072Antagonist activity at mu opioid receptor in guinea pig longitudinal muscle myenteric plexus assessed as inhibition of DAMGO-induced contraction after 10 mins [AID609732, Type: Literature]Mu-type opioid receptor [gi:3024265]
View
17
[SID134452400]
Ki 0.094Displacement of [3H]U-69,593 from kappa opioid receptor in dog brain after 90 mins by scintillation counting [AID649260, Type: Literature]
View
18
[SID134452400]
Ki 0.094Binding affinity to dog kappa opioid receptor [AID609730, Type: Literature]
View
19
[SID134452400]
Ki 0.183Binding affinity to dog delta opioid receptor [AID609731, Type: Literature]
View
20
[SID134452400]
Ki 0.183Displacement of [3H]DPDPE from delta opioid receptor in dog brain after 90 mins by scintillation counting [AID649259, Type: Literature]
View
21
[SID134452400]
 Antipruritic activity in dog with flea allergy dermatitis at 2 mg/kg, po upto 12 hrs [AID609736, Type: Literature]
View
22
[SID134452400]
 Inhibition of dog CYP2D15 [AID609737, Type: Literature]Cytochrome P450 2D15 [gi:2493366]
View
23
[SID134452400]
 Inhibition of morphine-induced antinociception in ICR mouse assessed as antagonism of morphine response to heat-induced tail flick at 10 mg/kg, sc preincubated for 15 mins before the addition of morphine assessed after 30 mins [AID609733, Type: Literature]
View
24
[SID134452400]
 Genotoxicity in Salmonella Typhimurium by Ames test [AID609734, Type: Literature]
View
25
[SID134452400]
 Genotoxicity in CHO cells by micronucleus assay [AID609735, Type: Literature]
View