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CHEMBL1834415 (CID 56661555) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Unspecified(9)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
 
BioAssay Types:
Literature(17)
 
 
 
BioActivity Types:
Ki(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 17    Data Row: 17   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134438317]
Ki 0.0132Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621887, Type: Literature]Mu-type opioid receptor [gi:2851402]
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2
[SID134438317]
Ki 0.0172Displacement of [3H]Cl-DPDPE from human DOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621888, Type: Literature]Delta-type opioid receptor [gi:311033488]
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3
[SID134438317]
Ki 0.0456Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621889, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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4
[SID134438317]
Ki 0.0678Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621019, Type: Literature]Nociceptin receptor [gi:730230]
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5
[SID134438317]
Antagonist activity at human NOP receptor expressed in CHO cells assessed as inhibition of nociceptin-stimulated [35S]GTPgammaS binding [AID621032, Type: Literature]Nociceptin receptor [gi:730230]
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6
[SID134438317]
Antagonist activity at human MOP receptor expressed in CHO cells assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding [AID621029, Type: Literature]Mu-type opioid receptor [gi:2851402]
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7
[SID134438317]
Antagonist activity at human KOP receptor expressed in CHO cells assessed as inhibition of U69593-stimulated [35S]GTPgammaS binding [AID621031, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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8
[SID134438317]
Antagonist activity at human DOP receptor expressed in CHO cells assessed as inhibition of DPDPE-stimulated [35S]GTPgammaS binding [AID621030, Type: Literature]Delta-type opioid receptor [gi:311033488]
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9
[SID134438317]
Partial agonist activity at human DOP receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting relative to DPDPE [AID621026, Type: Literature]Delta-type opioid receptor [gi:311033488]
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10
[SID134438317]
Selectivity ratio of Ki for human MOP receptor to Ki for human NOP receptor [AID621020, Type: Literature]
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11
[SID134438317]
Antinociceptive activity in CD1 mouse at 30 mg/kg, sc by tail flick assay [AID621033, Type: Literature]
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12
[SID134438317]
Antinociceptive activity in CD1 mouse assessed as inhibition of PPQ-induced writhing at 30 mg/kg, sc by tail flick assay [AID621034, Type: Literature]
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13
[SID134438317]
Antinociceptive activity in sc dosed CD1 mouse by tail flick assay [AID621035, Type: Literature]
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14
[SID134438317]
Antinociceptive activity in sc dosed CD1 mouse assessed as inhibition of PPQ-induced writhing by tail flick assay [AID621036, Type: Literature]
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15
[SID134438317]
Partial agonist activity at human KOP receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting relative to U69593 [AID621027, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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16
[SID134438317]
Partial agonist activity at human MOP receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting relative to DAMGO [AID621025, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
17
[SID134438317]
Partial agonist activity at human NOP receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting relative to nociceptin [AID621028, Type: Literature]Nociceptin receptor [gi:730230]
View