MLS002729058 (CID 56643207) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(14)
 
 
Inactive(120)
 
 
Inconclusive(2)
 
 
Unspecified(10)
 
 
Top Targets:
7TM GPCR Srx(7)
 
 
 
 
7TM GPCR Srsx(4)
 
 
NR DBD CAR(3)
 
 
 
PRK00058(2)
 
 
PTKc Abl(2)
 
 
BioAssay Types:
Screening(114)
 
 
 
Confirmatory(29)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
IC50(18)
 
 
 
 
Potency(11)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 130    Data Row: 146   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99495764]
Potency 2.8184qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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2
[SID99495764]
Potency 3.5481qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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3
[SID99495764]
Potency 3.5481qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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4
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_7, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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5
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_7, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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6
[SID99495764]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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7
[SID99495764]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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8
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_1, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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9
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_1, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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10
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_5, Type: confirmatory]CCR6 gene product [Homo sapiens] [gi:37187860]
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11
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_5, Type: confirmatory]CCR6 gene product [Homo sapiens] [gi:37187860]
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12
[SID99495764]
 Single concentration confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor via a luminescent beta-arrestin assay [AID602409, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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13
[SID99495764]
 Single concentration confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor via a luminescent beta-arrestin assay [AID602409, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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14
[SID99495764]
 Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_SinglePoint_HTS_Activity [AID651658, Type: screening]FGF22 gene product [Homo sapiens] [gi:10190672]
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15
[SID99495764]
 uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651582, Type: screening]
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16
[SID99495764]
 Single concentration confirmation of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651629, Type: screening]
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17
[SID99495764]
 Counterscreen for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl): Fluorescence-based biochemical high throughput assay to identify GFP inhibitors and fluorescence quenchers [AID602125, Type: screening]green fluorescent protein [Aequorea victoria] [gi:634009]
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18
[SID99495764]
 TRFRET-based biochemical high throughput confirmation assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID602124, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
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19
[SID99495764]
 TRFRET-based biochemical high throughput confirmation assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID602124, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
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20
[SID99495764]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
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21
[SID99495764]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
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22
[SID99495764]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12). [AID687014, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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23
[SID99495764]
IC50 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_2, Type: confirmatory]
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24
[SID99495764]
IC50 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_5, Type: confirmatory]
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25
[SID99495764]
IC50 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_6, Type: confirmatory]
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26
[SID99495764]
IC50 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_3, Type: confirmatory]
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27
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_6, Type: confirmatory]CCR6 gene product [Homo sapiens] [gi:37187860]
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28
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_6, Type: confirmatory]CCR6 gene product [Homo sapiens] [gi:37187860]
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29
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_2, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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30
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_2, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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31
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_3, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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32
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_3, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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33
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_8, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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34
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_8, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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35
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_9, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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36
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_9, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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37
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_10, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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38
[SID99495764]
IC50 Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_10, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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39
[SID99495764]
IC50 6.65Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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40
[SID99495764]
IC50 6.65Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129, Type: confirmatory]CXCR6 gene product [Homo sapiens] [gi:5730106]
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41
[SID99495764]
IC50 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_4, Type: confirmatory]
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42
[SID99495764]
IC50 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630, Type: confirmatory]
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43
[SID99495764]
IC50 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_1, Type: confirmatory]
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44
[SID99495764]
 Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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45
[SID99495764]
 VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]
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46
[SID99495764]
 uHTS identification of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay [AID624204, Type: screening]SENP1 gene product [Homo sapiens] [gi:7657550]
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47
[SID99495764]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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48
[SID99495764]
 PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_Activity [AID602405, Type: screening]WlaI protein (PglD) [gi:75495260]
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49
[SID99495764]
 Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotide [AID687016, Type: screening]UHRF1 gene product [Homo sapiens] [gi:115430235]
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50
[SID99495764]
 uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
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