MLS001008434 (CID 56642960) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(441)
 
 
Inconclusive(5)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
Peptidase C48(4)
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(314)
 
 
 
Confirmatory(129)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(98)
 
 
 
 
 
IC50(25)
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 452    Data Row: 452   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47198105]
Potency 39.8107qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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2
[SID47198105]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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3
[SID47198105]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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4
[SID47198105]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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5
[SID47198105]
 Confirmatory screen for compounds that activate the Choline Transporter (CHT) [AID504833, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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6
[SID47198105]
 Confirmatory screen for compounds that activate the Choline Transporter (CHT) [AID504833, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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7
[SID47198105]
 Counter screen assay of the parental HEK293 cells for compounds that activate the Choline Transporter (CHT) [AID623908, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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8
[SID47198105]
 Counter screen assay of the parental HEK293 cells for compounds that activate the Choline Transporter (CHT) [AID623908, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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9
[SID47198105]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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10
[SID47198105]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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11
[SID47198105]
Potency 25.1189qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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12
[SID47198105]
 qHTS Assay for Inhibitors of the Six1/Eya2 Interaction [AID651725, Type: screening]six1 [Homo sapiens] [gi:1246761]
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13
[SID47198105]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID47198105]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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15
[SID47198105]
 uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
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16
[SID47198105]
 High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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17
[SID47198105]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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18
[SID47198105]
 MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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19
[SID47198105]
IC50 A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus [AID1621, Type: confirmatory]
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20
[SID47198105]
 High Throughput Imaging Assay for Hepatic Lipid Droplet Formation [AID1656, Type: screening]
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21
[SID47198105]
 MLPCN Platelet Activation -Dense Granule Release [AID1663, Type: screening]
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22
[SID47198105]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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23
[SID47198105]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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24
[SID47198105]
 Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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25
[SID47198105]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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26
[SID47198105]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Polyadenylation [AID1875, Type: screening]
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27
[SID47198105]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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28
[SID47198105]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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29
[SID47198105]
 Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
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30
[SID47198105]
 Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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31
[SID47198105]
 Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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32
[SID47198105]
Potency qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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33
[SID47198105]
Potency qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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34
[SID47198105]
 uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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35
[SID47198105]
IC50 A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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36
[SID47198105]
Potency qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
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37
[SID47198105]
 A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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38
[SID47198105]
 Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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39
[SID47198105]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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40
[SID47198105]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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41
[SID47198105]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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42
[SID47198105]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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43
[SID47198105]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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44
[SID47198105]
 Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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45
[SID47198105]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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46
[SID47198105]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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47
[SID47198105]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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48
[SID47198105]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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49
[SID47198105]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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50
[SID47198105]
 uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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