MLS000573083 (CID 56642939) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Inactive(582)
 
 
Inconclusive(15)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
 
7TM GPCR Srsx(9)
 
 
NR LBD PPAR(6)
 
 
BioAssay Types:
Screening(407)
 
 
 
 
 
Confirmatory(181)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(133)
 
 
 
 
 
IC50(35)
 
 
EC50(8)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 603    Data Row: 603   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17432398]
Potency 0.7079qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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2
[SID17432398]
Potency 8.9125qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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3
[SID17432398]
 uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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4
[SID17432398]
 uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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5
[SID17432398]
 uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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6
[SID17432398]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
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7
[SID17432398]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
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8
[SID17432398]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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9
[SID17432398]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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10
[SID17432398]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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11
[SID17432398]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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12
[SID17432398]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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13
[SID17432398]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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14
[SID17432398]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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15
[SID17432398]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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16
[SID17432398]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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17
[SID17432398]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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18
[SID17432398]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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19
[SID17432398]
 uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphatase [AID2805, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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20
[SID17432398]
 uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase [AID2806, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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21
[SID17432398]
Potency qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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22
[SID17432398]
Potency qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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23
[SID17432398]
 uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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24
[SID17432398]
 uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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25
[SID17432398]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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26
[SID17432398]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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27
[SID17432398]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors [AID901, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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28
[SID17432398]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors [AID901, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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29
[SID17432398]
IC50 Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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30
[SID17432398]
 High-content cell-based screening for modulators of autophagy [AID463193, Type: screening]microtubule-associated proteins 1A/1B light chain 3A isoform b [Homo sapiens] [gi:31563518]
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31
[SID17432398]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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32
[SID17432398]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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33
[SID17432398]
 Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]Ano1 gene product [Mus musculus] [gi:334278898]
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34
[SID17432398]
 Primary cell-based high-throughput screening for identification of compounds that activate/potentiate calcium-activated chloride channels (TMEM16A) [AID623877, Type: screening]Ano1 gene product [Mus musculus] [gi:334278898]
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35
[SID17432398]
 uHTS Luminescent assay for identification of inhibitors of NALP3 in yeast [AID2825, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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36
[SID17432398]
 uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
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37
[SID17432398]
 HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
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38
[SID17432398]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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39
[SID17432398]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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40
[SID17432398]
 Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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41
[SID17432398]
 Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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42
[SID17432398]
 High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity [AID651819, Type: screening]TRIC [Homo sapiens] [gi:83758679]
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43
[SID17432398]
 Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
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44
[SID17432398]
Potency qHTS Assay for Inhibitors of the HIV-1 protein Vpr [AID651644, Type: confirmatory]Vpr [Human immunodeficiency virus 1] [gi:28872817]
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45
[SID17432398]
 TRFRET-based biochemical primary high throughput screening assay to identify small molecules that bind to the HIV-1-gp120 binding antibody, PG9 [AID624416, Type: screening]Envelope surface glycoprotein gp160, precursor [Human immunodeficiency virus 1] [gi:9629363]
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46
[SID17432398]
IC50 uHTS absorbance assay for the identification of compounds that inhibit PHOSPHO1 [AID1565, Type: confirmatory]phosphoethanolamine/phosphocholine phosphatase isoform 1 [Homo sapiens] [gi:219689097]
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47
[SID17432398]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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48
[SID17432398]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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49
[SID17432398]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels [AID2156, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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50
[SID17432398]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels [AID2156, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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