MLS000525802 (CID 56642896) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Inactive(615)
 
 
Inconclusive(8)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
alkPPc(12)
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(8)
 
 
Tryp SPc(8)
 
 
BioAssay Types:
Screening(433)
 
 
 
 
Confirmatory(179)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(128)
 
 
 
 
 
IC50(38)
 
 
EC50(8)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 627    Data Row: 627   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14724422]
Potency 19.9526qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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2
[SID14724422]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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3
[SID14724422]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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4
[SID14724422]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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5
[SID14724422]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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6
[SID14724422]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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7
[SID14724422]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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8
[SID14724422]
Potency 29.0929qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]snurportin-1 [Homo sapiens] [gi:5031833]
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9
[SID14724422]
Potency 35.4813qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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10
[SID14724422]
 uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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11
[SID14724422]
 Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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12
[SID14724422]
 Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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13
[SID14724422]
 Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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14
[SID14724422]
 uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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15
[SID14724422]
 uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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16
[SID14724422]
 HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening]
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17
[SID14724422]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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18
[SID14724422]
 Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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19
[SID14724422]
 HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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20
[SID14724422]
 Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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21
[SID14724422]
Potency qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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22
[SID14724422]
 Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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23
[SID14724422]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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24
[SID14724422]
 Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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25
[SID14724422]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening]
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26
[SID14724422]
 MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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27
[SID14724422]
 Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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28
[SID14724422]
 HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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29
[SID14724422]
 Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity [AID588436, Type: screening]
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30
[SID14724422]
 uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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31
[SID14724422]
 Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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32
[SID14724422]
 Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
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33
[SID14724422]
IC50 A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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34
[SID14724422]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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35
[SID14724422]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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36
[SID14724422]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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37
[SID14724422]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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38
[SID14724422]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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39
[SID14724422]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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40
[SID14724422]
 uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphatase [AID2805, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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41
[SID14724422]
 uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase [AID2806, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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42
[SID14724422]
Potency qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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43
[SID14724422]
 Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary Assay [AID1020, Type: screening]glucose-6-phosphate dehydrogenase [Leuconostoc mesenteroides] [gi:149631]
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44
[SID14724422]
Potency qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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45
[SID14724422]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2 [Saccharomyces cerevisiae] [gi:171229]
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46
[SID14724422]
 HTS of Smad transcription factor inhibitors [AID630, Type: screening]mothers against decapentaplegic homolog 3 [Homo sapiens] [gi:5174513]
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47
[SID14724422]
 HTS of Smad transcription factor inhibitors [AID630, Type: screening]mothers against decapentaplegic homolog 3 [Homo sapiens] [gi:5174513]
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48
[SID14724422]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]ASAP1 gene product [Homo sapiens] [gi:351542238]
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49
[SID14724422]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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50
[SID14724422]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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