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MLS001224314 (CID 56642873) - Compound BioActivity Data
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BioActivity Outcomes:
Active(76)
 
 
Inactive(440)
 
 
Inconclusive(17)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(15)
 
 
alkPPc(10)
 
 
 
Troponin(6)
 
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(347)
 
 
 
 
Confirmatory(173)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(124)
 
 
 
 
 
IC50(41)
 
 
 
EC50(5)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 483    Data Row: 534   Total Pages: 27   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49823732]
AC50_uM 0.461VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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2
[SID49823732]
Potency 0.631qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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3
[SID49823732]
Potency 1.4125qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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4
[SID49823732]
Potency 1.5003qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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5
[SID49823732]
Potency 1.5849qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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6
[SID49823732]
Potency 2.0575qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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7
[SID49823732]
IC50 2.08Fluorescent assay for identification of compounds that inhibit VHR1 [AID1878, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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8
[SID49823732]
Potency 2.1523qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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9
[SID49823732]
IC50 2.39Dose response confirmation of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID602386, Type: confirmatory]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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10
[SID49823732]
IC50_Mean 2.49Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a SUMO2 fluorescence resonance energy transfer selectivity assay [AID624384, Type: confirmatory]small ubiquitin-related modifier 2 isoform b precursor [Homo sapiens] [gi:54792071]
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11
[SID49823732]
Potency 2.5119qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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12
[SID49823732]
IC50_Mean 2.7Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay [AID488785, Type: confirmatory]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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13
[SID49823732]
Potency 4.4668qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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14
[SID49823732]
IC50 4.76uHTS absorbance assay for the identification of compounds that inhibit VHR1. [AID1654, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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15
[SID49823732]
Potency 5.4063qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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16
[SID49823732]
Potency 6.3096qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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17
[SID49823732]
IC50_Mean 6.82Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay [AID624383, Type: confirmatory]SUMO-1 [Homo sapiens] [gi:1762973]
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18
[SID49823732]
Potency 7.0795qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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19
[SID49823732]
Potency 7.0795qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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20
[SID49823732]
Potency 8.4368qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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