SMR000077825 (CID 56642854) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(11)
 
 
Inactive(692)
 
 
Inconclusive(10)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
alkPPc(10)
 
 
7TM GPCR Srsx(10)
 
 
Bcl-2 like(10)
 
 
P53(7)
 
 
BioAssay Types:
Screening(472)
 
 
 
 
 
Confirmatory(220)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(153)
 
 
 
 
 
IC50(36)
 
 
EC50(9)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 710    Data Row: 715   Total Pages: 15   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7965986]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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2
[SID7965986]
Potency 17.7828qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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3
[SID4264467]
Potency 19.9526qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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4
[SID7965986]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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5
[SID7965986]
 Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID651616, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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6
[SID7965986]
 Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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7
[SID7965986]
 Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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8
[SID4264467]
 qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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9
[SID4264467]
 qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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10
[SID4264467]
 Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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11
[SID7965986]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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12
[SID7965986]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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13
[SID7965986]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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14
[SID7965986]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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15
[SID7965986]
 HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]DRD2 gene product [Homo sapiens] [gi:4503385]
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16
[SID7965986]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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17
[SID7965986]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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18
[SID4264467]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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19
[SID4264467]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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20
[SID4264467]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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21
[SID4264467]
Potency 12.5893qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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22
[SID7965986]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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23
[SID7965986]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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24
[SID7965986]
Potency 39.8107qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]MEN1 gene product [Homo sapiens] [gi:18860839]
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25
[SID7965986]
Potency 50.1187qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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26
[SID7965986]
Potency 50.1187qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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27
[SID7965986]
Potency qHTS Assay for Agonists of the Relaxin Receptor RXFP1 [AID2676, Type: confirmatory]relaxin receptor 1 isoform 1 [Homo sapiens] [gi:85986601]
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28
[SID7965986]
Potency qHTS Assay for Agonists of the Relaxin Receptor RXFP1 [AID2676, Type: confirmatory]relaxin receptor 1 isoform 1 [Homo sapiens] [gi:85986601]
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29
[SID7965986]
 Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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30
[SID7965986]
 Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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31
[SID7965986]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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32
[SID7965986]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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33
[SID7965986]
 uHTS identification of APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493012, Type: screening]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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34
[SID7965986]
Potency qHTS for Inhibitors of Vif-A3G Interactions: qHTS [AID602310, Type: confirmatory]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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35
[SID4264467]
 Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC [AID556, Type: screening]diphosphomevalonate decarboxylase [Streptococcus pneumoniae D39] [gi:116076351]
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36
[SID4264467]
 Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC [AID556, Type: screening]diphosphomevalonate decarboxylase [Streptococcus pneumoniae D39] [gi:116076351]
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37
[SID4264467]
 Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - PMK [AID539, Type: screening]phosphomevalonate kinase [Streptococcus pneumoniae D39] [gi:116077694]
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38
[SID4264467]
 Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - MK [AID555, Type: screening]mevalonate kinase [Streptococcus pneumoniae D39] [gi:116516899]
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39
[SID7965986]
 Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B Interaction [AID2629, Type: screening]LANA [Human herpesvirus 8] [gi:139472804]
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40
[SID7965986]
 uHTS for Small Molecule Inhibitiors of Epstein-Barr Virus Inhibitors [AID1085, Type: screening]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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41
[SID7965986]
 Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_SinglePoint_HTS_Activity [AID488965, Type: screening]pvdQ gene product [Pseudomonas aeruginosa LESB58] [gi:218891639]
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42
[SID7965986]
 Fluorescence polarization to screen for inhibitor that competite the binding of FadD28 to bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_SinglePoint_HTS_Activity [AID588549, Type: screening]FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) [Mycobacterium tu [gi:1781172]
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43
[SID7965986]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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44
[SID7965986]
 Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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45
[SID7965986]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocyste [gi:219689243]
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46
[SID4264467]
 Cell Proliferation & Viability (Cytotoxicity) Primary Assay 60K MLSMR [AID463, Type: screening]
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47
[SID4264467]
 Primary HTS assay for chemical inhibitors of antigen receptor-induced NF-kappaB activation [AID465, Type: screening]
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48
[SID4264467]
 Ubiquitin-GFP Assay [AID526, Type: confirmatory]
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49
[SID4264467]
 Antimicrobial HTS Assay for E. coli BW25113 (wild type) [AID552, Type: screening]
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50
[SID4264467]
 Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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