Cefixime trihydrate (CID 56642849) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(53)
 
 
Inactive(343)
 
 
Inconclusive(8)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
WD40(6)
 
 
 
7TM GPCR Srsx(5)
 
 
TRP 2(5)
 
 
KCNQ channel(4)
 
 
BioAssay Types:
Screening(307)
 
 
 
 
Confirmatory(92)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(53)
 
 
 
 
 
IC50(23)
 
 
 
EC50(10)
 
 
 
 
AC50(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 405    Data Row: 405   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49648844]
EC50 0.06Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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2
[SID49648844]
EC50 0.06Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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3
[SID49648844]
EC50 0.06Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
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4
[SID49648844]
IC50 0.0764Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay [AID602361, Type: confirmatory]72 kDa type IV collagenase isoform a preproprotein [Homo sapiens] [gi:11342666]
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5
[SID49648844]
IC50 0.0764Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay [AID602361, Type: confirmatory]72 kDa type IV collagenase isoform a preproprotein [Homo sapiens] [gi:11342666]
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6
[SID49648844]
IC50 0.0764Dose Response validation of uHTS RPN11 inhibitor hits using a MMP-2 Fluorescence assay [AID602361, Type: confirmatory]72 kDa type IV collagenase isoform a preproprotein [Homo sapiens] [gi:11342666]
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7
[SID49648844]
Potency 0.1157qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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8
[SID49648844]
IC50 0.5Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay [AID624317, Type: confirmatory]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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9
[SID49648844]
IC50 1.04Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay [AID602368, Type: confirmatory]PSMD14 protein [Homo sapiens] [gi:16306916]
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10
[SID49648844]
IC50 4.25Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2 [AID651709, Type: confirmatory]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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11
[SID49648844]
EC50 9.93Dose Response confirmation of uHTS Activators of the Apaf-1 Pathway in Fluorescent format [AID588554, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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12
[SID49648844]
Potency 12.5893qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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13
[SID49648844]
Potency 14.1254HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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14
[SID49648844]
IC50 16.48A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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15
[SID49648844]
IC50 17.31A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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16
[SID49648844]
IC50 17.91A screen for inhibitors of the PhoP regulon in Salmonella Typhimurium using a modified counterscreen. [AID1981, Type: confirmatory]
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17
[SID49648844]
IC50 21.035A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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18
[SID49648844]
IC50 22.37A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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19
[SID49648844]
Potency 25.1189qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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20
[SID49648844]
IC50 30.31A Counter Screen to identiry small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID2401, Type: confirmatory]
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21
[SID49648844]
AC50 34.772C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity [AID504725, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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22
[SID49648844]
IC50 68.6Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay [AID602369, Type: confirmatory]prothrombin [Bos taurus] [gi:296479639]
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23
[SID49648844]
IC50 68.6Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay [AID602369, Type: confirmatory]prothrombin [Bos taurus] [gi:296479639]
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24
[SID49648844]
 uHTS identification of APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493011, Type: screening]APOBEC3A gene product [Homo sapiens] [gi:21955158]
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25
[SID49648844]
 Single concentration confirmation of uHTS for APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493151, Type: screening]APOBEC3A gene product [Homo sapiens] [gi:21955158]
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26
[SID49648844]
 uHTS identification of SUMO1-mediated protein-protein interactions [AID602429, Type: screening]SUMO-1 [Homo sapiens] [gi:1762973]
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27
[SID49648844]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
View
28
[SID49648844]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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29
[SID49648844]
 uHTS Colorimetric assay for identification of inhibitors of Scp-1 [AID493091, Type: screening]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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30
[SID49648844]
 Single concentration confirmation of uHTS Fluorescent assay for identification of activators of Apaf-1 [AID504617, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
View
31
[SID49648844]
 Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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32
[SID49648844]
 Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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33
[SID49648844]
 Counterscreen for RECBCD inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of AddAB recombination protein complex [AID651984, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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34
[SID49648844]
 MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
View
35
[SID49648844]
 Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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36
[SID49648844]
 Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) [AID651602, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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37
[SID49648844]
 Absorbance-based bacterial cell-based high throughput confirmation assay to identify inhibitors of RecBCD [AID651982, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
View
38
[SID49648844]
 uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
View
39
[SID49648844]
 Single concentration confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay [AID624309, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
View
40
[SID49648844]
 Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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41
[SID49648844]
 Counterscreen for inhibitors of RecBCD: Absorbance-based cell-based high throughput assay to identify inhibitors of bacterial viability [AID651983, Type: screening]
View
42
[SID49648844]
 C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity [AID504423, Type: screening]LANA [Human herpesvirus 8] [gi:312275222]
View
43
[SID49648844]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID686964, Type: screening]Methyl-CpG binding domain protein 2 [Homo sapiens] [gi:21595776]
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44
[SID49648844]
 Single concentration confirmation of uHTS inhibitor hits from RPN11 in a Fluorescence Polarization assay [AID602318, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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45
[SID49648844]
 uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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46
[SID49648844]
 Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID651800, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
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47
[SID49648844]
 Fluorescence-based biochemical primary high throughput confirmation assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID652036, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
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48
[SID49648844]
 MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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49
[SID49648844]
 MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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50
[SID49648844]
 uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
View