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MLS001210139 (CID 56603498) - Compound BioActivity Data
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BioActivity Outcomes:
Active(35)
 
 
Inactive(181)
 
 
Inconclusive(30)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
 
7TM GPCR Srx(7)
 
 
CAP ED(4)
 
 
RasGEF(4)
 
 
 
ZnMc TACE lik..(4)
 
 
 
BioAssay Types:
Screening(173)
 
 
 
 
Confirmatory(59)
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(44)
 
 
 
 
IC50(11)
 
 
 
 
AC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 227    Data Row: 246   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99494336]
IC50_Mean 2.5Dose response confirmation of uHTS inhibitor hits of the mitochondrial permeability transition pore via a fluorescent based counterscreen assay [AID651564, Type: confirmatory]
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2
[SID99494336]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID99494336]
IC50_MT1-MMP(HT1080)_Mean 6.17Dose Response confirmation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluorescence assay set 2 [AID652242, Type: confirmatory]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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4
[SID99494336]
Potency 7.9433qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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5
[SID99494336]
AC50_uM 18.37FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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6
[SID99494336]
AC50_uM 35.76C. difficile toxins: Counterscreen in absence of substrate UDPG Measured in Biochemical System Using Plate Reader - 7074-02_Inhibitor_Dose_CherryPick_Activity [AID720650, Type: confirmatory]
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7
[SID99494336]
AC50_uM 38.28RAD52: DNA binders Measured in Biochemical System Using Plate Reader - 7018-02_Inhibitor_Dose_CherryPick_Activity [AID652128, Type: confirmatory]
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8
[SID99494336]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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9
[SID99494336]
C. difficile toxins: HTS for inhibitors of TcdB glycohydrolase activity Measured in Biochemical System Using Plate Reader - 7074-01_Inhibitor_SinglePoint_HTS_Activity [AID652162, Type: screening]toxin B [Clostridium difficile 630] [gi:126698238]
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10
[SID99494336]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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11
[SID99494336]
Single concentration validation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluoresence assay [AID652235, Type: screening]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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12
[SID99494336]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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13
[SID99494336]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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14
[SID99494336]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-beta3). [AID720704, Type: screening]Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [gi:148745659]
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15
[SID99494336]
HTS for Bacterial rRNA inhibitors Measured in Microorganism-Based System Using Plate Reader - 7056-01_Inhibitor_SinglePoint_HTS_Activity [AID720706, Type: screening]
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16
[SID99494336]
QFRET-based biochemical high throughput primary assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) [AID743126, Type: screening]phospholipase A2, group III [Homo sapiens] [gi:119580345]
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17
[SID99494336]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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18
[SID99494336]
uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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19
[SID99494336]
Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]hepatocyte nuclear factor 4-alpha isoform HNF4alpha2 [Homo sapiens] [gi:31077205]
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20
[SID99494336]
Counter screen in the myeloid differentiation screening campaign for compound fluorescence with Cherry Pick01 [AID651707, Type: other]
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