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MLS001210139 (CID 56603498) - Compound BioActivity Data
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BioActivity Outcomes:
Active(35)
 
 
Inactive(183)
 
 
Inconclusive(30)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
 
7TM GPCR Srx(7)
 
 
CAP ED(4)
 
 
ZnMc TACE lik..(4)
 
 
 
RasGEF(4)
 
 
 
BioAssay Types:
Screening(175)
 
 
 
 
Confirmatory(59)
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(44)
 
 
 
 
IC50(11)
 
 
 
 
AC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 229    Data Row: 248   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99494336]
IC50_Mean 2.5Dose response confirmation of uHTS inhibitor hits of the mitochondrial permeability transition pore via a fluorescent based counterscreen assay [AID651564, Type: confirmatory]
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2
[SID99494336]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID99494336]
IC50_MT1-MMP(HT1080)_Mean 6.17Dose Response confirmation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluorescence assay set 2 [AID652242, Type: confirmatory]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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4
[SID99494336]
Potency 7.9433qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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5
[SID99494336]
AC50_uM 18.37FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog isoform a [Homo sapiens] [gi:109637798]
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6
[SID99494336]
AC50_uM 35.76C. difficile toxins: Counterscreen in absence of substrate UDPG Measured in Biochemical System Using Plate Reader - 7074-02_Inhibitor_Dose_CherryPick_Activity [AID720650, Type: confirmatory]
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7
[SID99494336]
AC50_uM 38.28RAD52: DNA binders Measured in Biochemical System Using Plate Reader - 7018-02_Inhibitor_Dose_CherryPick_Activity [AID652128, Type: confirmatory]
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8
[SID99494336]
Counter screen in the myeloid differentiation screening campaign for compound fluorescence with Cherry Pick01 [AID651707, Type: other]
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9
[SID99494336]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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10
[SID99494336]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Activator_SinglePoint_HTS_Activity [AID623901, Type: screening]
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11
[SID99494336]
HTS for Bacterial rRNA inhibitors Measured in Microorganism-Based System Using Plate Reader - 7056-01_Inhibitor_SinglePoint_HTS_Activity [AID720706, Type: screening]
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12
[SID99494336]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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13
[SID99494336]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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14
[SID99494336]
uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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15
[SID99494336]
uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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16
[SID99494336]
Single concentration validation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluoresence assay [AID652235, Type: screening]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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17
[SID99494336]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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18
[SID99494336]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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19
[SID99494336]
uHTS identification of SKN-1 Inhibitors in a fluoresence assay [AID624304, Type: screening]Protein SKN-1, isoform b [Caenorhabditis elegans] [gi:25148072]
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20
[SID99494336]
Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]hepatocyte nuclear factor 4-alpha isoform HNF4alpha2 [Homo sapiens] [gi:31077205]
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