(4-([1,1'-Biphenyl]-4-yl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone (CID 56593029) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Probe(1)
 
 
Active(9)
 
 
Inactive(50)
 
 
Unspecified(5)
 
 
Top Targets:
Peptidase S9(24)
 
 
 
 
 
BAAT C(2)
 
 
Pat PNPLA6 PN..(2)
 
 
PRK11460(2)
 
 
Lipase(2)
 
 
BioAssay Types:
Confirmatory(5)
 
 
 
Summary(4)
 
 
 
BioActivity Types:
IC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 11    Data Row: 65   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103913572]
 Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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2
[SID103913572]
 Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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3
[SID103913572]
IC50 0.003Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) IC50 [AID504494, Type: confirmatory]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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4
[SID103913572]
IC50 170Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: fluorescence-based cell-based gel-based Activity-Based Protein Profiling (ABPP) IC50 [AID504496, Type: confirmatory]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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5
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) inhibition and selectivity [AID504513, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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6
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) inhibition and selectivity [AID504513_1, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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7
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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8
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_1, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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9
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: fluorescence-based cell-based gel-based Activity-Based Protein Profiling (ABPP) inhibition [AID504495, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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10
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) assay to assess selectivity against anti-target pPAFAH in situ [AID504531, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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11
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS/MS assay to assess binding of compounds to active site [AID504486, Type: other]unnamed protein product [Homo sapiens] [gi:189054044]
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12
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS/MS assay to assess binding of compounds to active site [AID504486, Type: other]unnamed protein product [Homo sapiens] [gi:189054044]
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13
[SID103913572]
IC50 0.003Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969_1, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
View
14
[SID103913572]
IC50 0.003Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969_1, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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15
[SID103913572]
CC50 35Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969_2, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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16
[SID103913572]
CC50 35Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969_2, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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17
[SID103913572]
CC50 50Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969_3, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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18
[SID103913572]
CC50 50Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969_3, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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19
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) assay to assess selectivity against anti-target pPAFAH in situ [AID504531_1, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic [Mus musculus] [gi:225579137]
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20
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) assay to assess selectivity against anti-target pPAFAH in situ [AID504531_2, Type: other]Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus] [gi:14715116]
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21
[SID103913572]
 35Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: absorbance-based cell-based dose response assay to determine cytotoxicity of inhibitor compounds [AID504511_1, Type: confirmatory]
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22
[SID103913572]
 50Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: absorbance-based cell-based dose response assay to determine cytotoxicity of inhibitor compounds [AID504511_2, Type: confirmatory]
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23
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) counterscreen assay to assess selectivity against anti-target pPAFAH in vitro [AID504483, Type: other]phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus] [gi:168984061]
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24
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_30, Type: other]Pafah1b3 gene product [Mus musculus] [gi:6679201]
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25
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_23, Type: other]Prepl protein [Mus musculus] [gi:13435484]
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26
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_34, Type: other]Dpp9 gene product [Mus musculus] [gi:255003757]
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27
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_16, Type: other]abhydrolase domain-containing protein 13 [Mus musculus] [gi:299473802]
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28
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_33, Type: other]Lactamase, beta [Mus musculus] [gi:187955464]
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29
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_18, Type: other]platelet-activating factor acetylhydrolase isoform Ib beta subunit [Mus musculus] [gi:1373363]
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30
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of diacylglycerol lipase, beta (DAGLb): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of overexpressed DAGLb in vitro; triazole urea library [AID602303, Type: other]Daglb gene product [Mus musculus] [gi:31559956]
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31
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of diacylglycerol lipase, beta (DAGLb): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of overexpressed DAGLb in vitro; triazole urea library [AID602303, Type: other]Daglb gene product [Mus musculus] [gi:31559956]
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32
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: absorbance-based cell-based dose response assay to determine cytotoxicity of inhibitor compounds [AID504511, Type: confirmatory]
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33
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_22, Type: other]Family with sequence similarity 108, member C [Mus musculus] [gi:17391206]
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34
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_4, Type: other]Apeh protein [Mus musculus] [gi:20072022]
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35
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) inhibition and selectivity [AID504513_2, Type: other]Apeh protein [Mus musculus] [gi:20072022]
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36
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_2, Type: other]Abhydrolase domain containing 6 [Mus musculus] [gi:20073260]
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37
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_12, Type: other]Acyl-CoA thioesterase 1 [Mus musculus] [gi:20380528]
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38
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_39, Type: other]Ddhd1 protein [Mus musculus] [gi:27694042]
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39
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_14, Type: other]Iah1 gene product [Mus musculus] [gi:27754071]
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40
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_27, Type: other]Abhd16a gene product [Mus musculus] [gi:30519896]
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41
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_9, Type: other]Ppme1 gene product [Mus musculus] [gi:30794138]
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42
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_37, Type: other]Prcp protein [Mus musculus] [gi:32967631]
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43
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_42, Type: other]Pnpla6 protein [Mus musculus] [gi:34784201]
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44
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_3, Type: other]Pla2g6 protein [Mus musculus] [gi:34784362]
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45
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_35, Type: other]Abhydrolase domain containing 10 [Mus musculus] [gi:37231537]
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46
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_31, Type: other]Dipeptidylpeptidase 8 [Mus musculus] [gi:37590654]
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47
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_15, Type: other]Acyl-CoA thioesterase 2 [Mus musculus] [gi:39992610]
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48
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) inhibition and selectivity [AID504513_3, Type: other]Abhydrolase domain containing 11 [Mus musculus] [gi:47682716]
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49
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_38, Type: other]Abhydrolase domain containing 11 [Mus musculus] [gi:47682716]
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50
[SID103913572]
 Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_32, Type: other]Arylacetamide deacetylase-like 1 [Mus musculus] [gi:52139053]
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