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(4-([1,1'-Biphenyl]-4-yl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone (CID 56593029) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(9)
 
 
Inactive(50)
 
 
Unspecified(5)
 
 
Top Targets:
PAF-AH p II(10)
 
 
 
 
Peptidase S9(7)
 
 
Hydrolase 4(6)
 
 
Peptidase S9(5)
 
 
Abhydrolase 2(2)
 
 
BioAssay Types:
Confirmatory(5)
 
 
 
Summary(4)
 
 
 
BioActivity Types:
IC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 11    Data Row: 65   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103913572]
Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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2
[SID103913572]
IC50 0.003Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) IC50 [AID504494, Type: confirmatory]platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b [Mus musculus] [gi:225579137]
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3
[SID103913572]
IC50 170Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: fluorescence-based cell-based gel-based Activity-Based Protein Profiling (ABPP) IC50 [AID504496, Type: confirmatory]platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b [Mus musculus] [gi:225579137]
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4
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) inhibition and selectivity [AID504513_1, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b [Mus musculus] [gi:225579137]
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5
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_1, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b [Mus musculus] [gi:225579137]
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6
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: fluorescence-based cell-based gel-based Activity-Based Protein Profiling (ABPP) inhibition [AID504495, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b [Mus musculus] [gi:225579137]
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7
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS/MS assay to assess binding of compounds to active site [AID504486, Type: other]unnamed protein product [Homo sapiens] [gi:189054044]
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8
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) inhibition and selectivity [AID504513, Type: other]
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9
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519, Type: other]
View
10
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) assay to assess selectivity against anti-target pPAFAH in situ [AID504531, Type: other]
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11
[SID103913572]
IC50 [AID 504494] 0.003Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969_1, Type: summary]platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b [Mus musculus] [gi:225579137]
View
12
[SID103913572]
CC50 [AID 504511_1] 35Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969_2, Type: summary]
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13
[SID103913572]
CC50 [AID 504511_2] 50Summary of the probe development efforts to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492969_3, Type: summary]
View
14
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) assay to assess selectivity against anti-target pPAFAH in situ [AID504531_1, Type: other]platelet-activating factor acetylhydrolase 2, cytoplasmic isoform b [Mus musculus] [gi:225579137]
View
15
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: Fluorescence-based biochemical gel-based Activity-Based Protein Profiling (ABPP) assay to assess selectivity against anti-target pPAFAH in situ [AID504531_2, Type: other]Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus] [gi:14715116]
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16
[SID103913572]
35Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: absorbance-based cell-based dose response assay to determine cytotoxicity of inhibitor compounds [AID504511_1, Type: confirmatory]
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17
[SID103913572]
50Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: absorbance-based cell-based dose response assay to determine cytotoxicity of inhibitor compounds [AID504511_2, Type: confirmatory]
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18
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_22, Type: other]Family with sequence similarity 108, member C [Mus musculus] [gi:17391206]
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19
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_12, Type: other]Acyl-CoA thioesterase 1 [Mus musculus] [gi:20380528]
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20
[SID103913572]
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2 [AID504519_14, Type: other]isoamyl acetate-hydrolyzing esterase 1 homolog [Mus musculus] [gi:27754071]
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