venlafaxine (CID 5656) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(29)
 
 
Inactive(214)
 
 
Inconclusive(23)
 
 
Unspecified(233)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
 
 
p450(12)
 
 
 
7TM GPCR Srsx(10)
 
 
 
SLC6sbd SERT(6)
 
 
SLC6sbd NET(5)
 
 
BioAssay Types:
Literature(199)
 
 
 
 
 
Confirmatory(129)
 
 
 
 
Screening(28)
 
 
BioActivity Types:
IC50(136)
 
 
 
Potency(128)
 
 
 
 
Ki(6)
 
 
Kd(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 418    Data Row: 499   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103188954]
IC50 0.00718DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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2
[SID103188954]
IC50 0.00718DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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3
[SID103188954]
IC50 0.00718DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID103188954]
Kd 0.0089Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT [AID204080, Type: Literature]
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5
[SID103188954]
IC50 0.027Inhibition of human SERT expressed in human JAR cells [AID481498, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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6
[SID103188954]
IC50 0.027Inhibition of human SERT expressed in human JAR cells [AID481498, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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7
[SID103188954]
IC50 0.027Inhibition of human SERT expressed in human JAR cells [AID481498, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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8
[SID103188954]
IC50 0.031Inhibition of 5HT uptake at human SERT expressed in human JAR cells [AID339394, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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9
[SID103188954]
IC50 0.031Inhibition of 5HT uptake at human SERT expressed in human JAR cells [AID339394, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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10
[SID103188954]
IC50 0.031Inhibition of 5HT uptake at human SERT expressed in human JAR cells [AID339394, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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11
[SID103188954]
IC50 0.035Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells [AID504077, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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12
[SID103188954]
IC50 0.035Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells [AID504077, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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13
[SID103188954]
IC50 0.035Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells [AID504077, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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14
[SID103188954]
Ki 0.037Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomes [AID186981, Type: Literature]
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15
[SID103188954]
Ki 0.052Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats [AID204534, Type: Literature]
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16
[SID103188954]
IC50 0.09Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain [AID91721, Type: Literature]
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17
[SID103188954]
Ki 0.138Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomes [AID186980, Type: Literature]
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18
[SID103188954]
IC50 0.21Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes [AID180133, Type: Literature]
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19
[SID103188954]
IC50 0.21Inhibition of 5HT uptake at rat brain SERT [AID339399, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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20
[SID103188954]
IC50 0.35Inhibition of [3H]5HT reuptake at rat brain frontal cortex serotonin transporter [AID457710, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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21
[SID103188954]
Ki 0.36Inhibition of [3H]- DA reuptake into rat striatal synaptosomes [AID186979, Type: Literature]
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22
[SID103188954]
Ki 0.385Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells [AID339392, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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23
[SID103188954]
Ki 0.385Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells [AID339392, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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24
[SID103188954]
IC50 0.535Inhibition of norepinephrine uptake at human norepinephrine transporter expressed in MDCK-Net6 cells [AID339393, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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25
[SID103188954]
IC50 0.535Inhibition of norepinephrine uptake at human norepinephrine transporter expressed in MDCK-Net6 cells [AID339393, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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26
[SID103188954]
IC50 0.535Inhibition of human NET transfected in MDCK-Net6 cells [AID481497, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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27
[SID103188954]
IC50 0.535Inhibition of human NET transfected in MDCK-Net6 cells [AID481497, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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28
[SID103188954]
IC50 0.581Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells [AID504078, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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29
[SID103188954]
IC50 0.581Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells [AID504078, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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30
[SID103188954]
IC50 0.64Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes [AID180132, Type: Literature]
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31
[SID103188954]
IC50 0.64Inhibition of norepinephrine uptake at rat brain norepinephrine transporter [AID339398, Type: Literature]Norepinephrine transporter [gi:81890335]
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32
[SID103188954]
Ki 0.719Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar rats [AID147740, Type: Literature]
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33
[SID103188954]
Kd 1.06Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporter [AID145563, Type: Literature]
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34
[SID103188954]
IC50 1.4Inhibition of [3H]norepinephrine reuptake at rat brain frontal cortex norepinephrine transporter [AID457709, Type: Literature]Norepinephrine transporter [gi:81890335]
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35
[SID103188954]
IC50 2.708DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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36
[SID103188954]
IC50 2.708DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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37
[SID90341232]
Potency 5.3582qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485368, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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38
[SID103188954]
IC50 7.34Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells [AID504076, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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39
[SID103188954]
IC50 7.34Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells [AID504076, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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40
[SID103188954]
IC50 7.34Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells [AID504076, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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41
[SID103188954]
IC50 7.34Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells [AID504076, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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42
[SID103188954]
Kd 9.3Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDAT [AID64372, Type: Literature]
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43
[SID48416696]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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44
[SID26748923]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
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45
[SID26748923]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_24, Type: Literature]
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46
[SID103188954]
IC50 1Binding affinity against dopamine transporter (DAT) by displacement of [3H]WIN-35428 in male wistar rats [AID64685, Type: Literature]
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47
[SID103188954]
IC50 1Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranes [AID3719, Type: Literature]
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48
[SID103188954]
IC50 1Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranes [AID5476, Type: Literature]
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49
[SID103188954]
IC50 10Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes [AID481499, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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50
[SID103188954]
IC50 10Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranes [AID481499, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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