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Trifluralin (CID 5569) - Compound BioActivity Data
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BioActivity Outcomes:
Active(24)
 
 
Inactive(377)
 
 
Inconclusive(46)
 
 
Unspecified(17)
 
 
Top Targets:
NR LBD PPAR(26)
 
 
 
NR LBD ER(18)
 
 
 
NR LBD AR(18)
 
 
 
NR LBD TR(16)
 
 
 
NR LBD VDR(13)
 
 
 
BioAssay Types:
Confirmatory(358)
 
 
 
 
 
Summary(48)
 
 
 
 
Literature(32)
 
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(355)
 
 
 
 
 
IC50(19)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 305    Data Row: 464   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103201942]
IC50 0.52Antmicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay [AID522805, Type: Literature]
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2
[SID103201942]
IC50 0.65Antimicrobial activity against Toxoplasma gondii infected in HFF after 8 days by plaque assay [AID502117, Type: Literature]
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3
[SID103201942]
IC50 0.75Antimicrobial activity against Cryptosporidium parvum infected in HCT8 cells assessed as parasite count after 72 to 120 hrs [AID622161, Type: Literature]
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4
[SID103201942]
EC50 1.32Antitubulin activity in tobacco root assay. [AID214506, Type: Literature]
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5
[SID103201942]
IC50 1.8Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay [AID522813, Type: Literature]
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6
[SID103201942]
IC50 1.9Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay [AID522811, Type: Literature]
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7
[SID103201942]
IC50 1.94Antmicrobial activity against Cryptosporidium parvum by short-term in vitro culture assay [AID522819, Type: Literature]
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8
[SID103201942]
IC50 2.8Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay [AID522807, Type: Literature]
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9
[SID103201942]
IC50 2.9Antimicrobial activity against Plasmodium falciparum [AID622162, Type: Literature]
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10
[SID103201942]
IC50 4.1Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay [AID522815, Type: Literature]
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11
[SID103201942]
IC50 4.2Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay [AID522808, Type: Literature]
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12
[SID17388681]
Potency 5.0119qHTS Assay for Anthrax Lethal Toxin Internalization [AID912, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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13
[SID103201942]
IC50 5.1Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay [AID522812, Type: Literature]
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14
[SID103201942]
IC50 5.3Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay [AID522809, Type: Literature]
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15
[SID103201942]
IC50 13.8Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay [AID522806, Type: Literature]
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16
[SID103201942]
IC50 23.3Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay [AID522816, Type: Literature]
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17
[SID103201942]
IC50 23.4Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay [AID522814, Type: Literature]
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18
[SID103201942]
IC50 27Antmicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay [AID522810, Type: Literature]
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19
[SID144208550]
Ratio Potency (uM) 33.0147qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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20
[SID144211235]
Ratio Potency (uM) 66.0073qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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21
[SID48414585]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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22
[SID48414585]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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23
[SID48414585]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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24
[SID48414585]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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25
[SID17388681]
Potency 12.5893qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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26
[SID103201942]
CC50 50Cytotoxicity against human THP1 cells after 48 hrs by propidium iodide and SYBR14 satining-base flow cytometry [AID456119, Type: Literature]
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27
[SID103201942]
IC50 50Antileishmanial activity against Leishmania infantum A1 amastigotes infected in human THP1 cells assessed as reduction in intracellular parasite load after 48 hrs by Giemsa staining [AID456124, Type: Literature]
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28
[SID103201942]
IC50 100Antileishmanial activity against Leishmania infantum MHOM/TN/80/IPT1/LEM 235 promastigotes after 72 hrs by propidium iodide and SYBR14 satining-base flow cytometry [AID456122, Type: Literature]
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29
[SID103201942]
IC50 100Antileishmanial activity against Leishmania donovani MHOM/IN/80/DD8/LEM 703 promastigotes after 72 hrs by propidium iodide and SYBR14 satining-base flow cytometry [AID456123, Type: Literature]
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30
[SID103201942]
Ratio of miltefosine HC50 to compound HC50 for human RBC [AID456126, Type: Literature]
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31
[SID103201942]
Cytotoxicity against human RBC assessed as hemolysis after 1 hr by microplate reader method [AID456120, Type: Literature]
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32
[SID103201942]
Cytotoxicity against human RBC assessed as hemolysis at 100 uM after 1 hr by microplate reader method [AID456121, Type: Literature]
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33
[SID17388681]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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34
[SID26752965]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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35
[SID103201942]
Octanol-water partition coefficient, log KOW of the compound [AID289345, Type: Literature]
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36
[SID103201942]
Octanol-air partition coefficient, log KOA of the compound [AID289346, Type: Literature]
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37
[SID103201942]
Biomagnification factors in Diporeia [AID289347, Type: Literature]
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38
[SID103201942]
Biomagnification factors in human [AID289348, Type: Literature]
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39
[SID103201942]
Anticarcinogenic activity in rat assessed as induction of tumors per day [AID318681, Type: Literature]
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40
[SID103201942]
Hepatotoxicity in mouse assessed as carcinogenic potency [AID433903, Type: Literature]
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41
[SID103201942]
Aqueous solubility in water by NMR spectrophotometry [AID456118, Type: Literature]
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42
[SID17388681]
Potency 15.8489qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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43
[SID26747330]
Potency 15.8489qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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44
[SID26747330]
Potency 35.4813qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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45
[SID144208550]
Potency-Replicate_1 43.5664qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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46
[SID144211235]
Potency-Replicate_1 43.6412qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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47
[SID17388681]
Potency 63.0957qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
View
48
[SID144211235]
Potency-Replicate_1 68.5896qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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49
[SID144208550]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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50
[SID144208550]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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