Trifluoperazine (CID 5566) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(135)
 
 
Inactive(520)
 
 
Inconclusive(113)
 
 
Unspecified(240)
 
 
Top Targets:
p450(31)
 
 
 
 
 
7TM GPCR Srx(30)
 
 
 
 
7TM GPCR Srsx(15)
 
 
 
NR LBD TR(8)
 
 
Pyr redox dim(8)
 
 
 
 
BioAssay Types:
Confirmatory(399)
 
 
 
 
 
Literature(240)
 
 
 
 
 
Screening(188)
 
 
 
 
BioActivity Types:
Potency(317)
 
 
 
 
 
IC50(171)
 
 
 
 
 
Ki(11)
 
 
 
Kd(8)
 
 
AC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 730    Data Row: 1008   Total Pages: 21   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164917]
Kd 0.000532Compound was tested for its effect on dopamine saturation analysis [AID61331, Type: Literature]
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2
[SID103164917]
Kd 0.00104Compound was tested for its effect on 5-hydroxytryptamine 2 receptor saturation analysis [AID4848, Type: Literature]
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3
[SID103164917]
Ki 0.0022Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum [AID65908, Type: Literature]
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4
[SID103164917]
Ki 0.0052The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cortex [AID5307, Type: Literature]
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5
[SID103164917]
Ki 0.008Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand [AID239597, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:17374795]
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6
[SID103164917]
Ki 0.015Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand [AID239347, Type: Literature]
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7
[SID103164917]
IC50 0.016Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperone [AID61326, Type: Literature]
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8
[SID103164917]
Ki 0.0242Inhibition of human monobromobimane tagged-calmodulin L39C/V91C mutant by fluorescence spectrophotometric analysis [AID605819, Type: Literature]
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9
[SID103164917]
Ki 0.0293The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex [AID35435, Type: Literature]
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10
[SID4252673]
Potency 0.3162qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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11
[SID103164917]
IC50 0.35In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101 [AID36847, Type: Literature]
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12
[SID103164917]
Ki 0.411Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus [AID4362, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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13
[SID103164917]
Ki 0.411Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus [AID4362, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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14
[SID103164917]
Kd 0.5Binding affinity to human monobromobimane tagged-calmodulin L39C/V91C mutant by fluorescence spectrophotometric analysis in presence of 10 uM calcium ions [AID605818, Type: Literature]
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15
[SID103164917]
Ki 0.5Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand [AID239296, Type: Literature]
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16
[SID103164917]
IC50 0.7Inhibitory concentration against hepatitis C virus helicase; range 0.6-0.7 [AID241445, Type: Literature]
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17
[SID103164917]
Kd 0.8Binding affinity to human monobromobimane tagged-calmodulin L39C/V91C mutant by fluorescence spectrophotometric analysis in presence of 7.5 uM calcium ions [AID605817, Type: Literature]
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18
[SID90341087]
Potency 0.8913HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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19
[SID90341087]
Potency 0.8913HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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20
[SID90341087]
Potency 0.8913HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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21
[SID90341087]
Potency 0.8913HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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22
[SID103164917]
Kd 1Binding affinity to human monobromobimane tagged-calmodulin L39C/V91C mutant by fluorescence spectrophotometric analysis in presence of 5 uM calcium ions [AID605816, Type: Literature]
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23
[SID103164917]
Kd 1Binding affinity to calmodulin [AID404335, Type: Literature]
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24
[SID11110645]
Potency 1qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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25
[SID103164917]
IC50 1.4Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay [AID581672, Type: Literature]
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26
[SID11110644]
Potency 1.9953qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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27
[SID4252673]
Potency 1.9953qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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28
[SID4252673]
Potency 1.9953qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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29
[SID103164917]
Kd 2.1Binding affinity to human monobromobimane tagged-calmodulin L39C/V91C mutant by fluorescence spectrophotometric analysis in presence of 2.5 uM calcium ions [AID607092, Type: Literature]
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30
[SID103164917]
IC50 2.7Inhibition of PMA-induced superoxide formation in Sprague-Dawley rat neutrophil [AID264912, Type: Literature]
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31
[SID103164917]
IC50 2.7Inhibitory effect of compound on superoxide anion generation in rat neutrophils stimulated with PMA [AID180321, Type: Literature]
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32
[SID103164917]
IC50 3.15Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562245, Type: Literature]
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33
[SID103164917]
IC50 3.15Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562242, Type: Literature]
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34
[SID124877145]
Potency 3.7192qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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35
[SID124877144]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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36
[SID103164917]
IC50 5Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
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37
[SID124877144]
Potency 5.1735qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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38
[SID103164917]
Kd 5.7Binding affinity to human monobromobimane tagged-calmodulin L39C/V91C mutant by fluorescence spectrophotometric analysis [AID607091, Type: Literature]
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39
[SID103164917]
IC50 6Antimicrobial activity against Plasmodium falciparum [AID496819, Type: Literature]
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40
[SID103164917]
IC50 6.226DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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41
[SID103164917]
IC50 6.226DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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42
[SID103164917]
IC50 6.226DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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43
[SID103164917]
IC50 6.226DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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44
[SID103164917]
IC50 6.226DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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45
[SID103164917]
Ki 6.5Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affinity model [AID150616, Type: Literature]
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46
[SID90341087]
Potency 6.5104qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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47
[SID103164917]
IC50 6.6Inhibitory effect of compound on superoxide anion generation in rat neutrophils stimulated with fMLP/CB [AID180322, Type: Literature]
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48
[SID103164917]
IC50 6.6Inhibition of fMLP-induced superoxide formation in Sprague-Dawley rat neutrophil [AID264899, Type: Literature]
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49
[SID124877145]
Potency 6.6138qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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50
[SID90341087]
Potency 7.3048qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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