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Triclosan (CID 5564) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(228)
 
 
Inactive(570)
 
 
Inconclusive(121)
 
 
Unspecified(183)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
 
NR LBD AR(16)
 
 
 
 
NR LBD ER(16)
 
 
 
7TM GPCR Srsx(15)
 
 
 
7TM GPCR Srx(14)
 
 
 
BioAssay Types:
Screening(362)
 
 
 
Confirmatory(334)
 
 
 
 
 
Literature(333)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(340)
 
 
 
 
 
IC50(64)
 
 
 
 
 
Ki(19)
 
 
EC50(11)
 
 
 
AC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 875    Data Row: 1102   Total Pages: 23   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103222736]
Ki 1.9e-06Inhibition of Plasmodium falciparum ENR in presence of EGCG by dilution assay [AID277593, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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2
[SID103222736]
Ki 5.21e-05Inhibition of Plasmodium falciparum ENR in presence of ECG by dilution assay [AID277595, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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3
[SID103222736]
Ki 0.000109Inhibition of Plasmodium falciparum ENR in presence of EGC by dilution assay [AID277594, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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4
[SID103222736]
Ki 0.000281Inhibition of Plasmodium falciparum ENR in presence of quercetin by dilution assay [AID277596, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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5
[SID103222736]
Ki 0.000798Inhibition of Plasmodium falciparum ENR in presence of butein by dilution assay [AID277597, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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6
[SID103222736]
Ki 0.001Inhibition of Plasmodium falciparum ENR in presence of EGCG [AID277598, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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7
[SID103222736]
Ki 0.00729Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of EGCG [AID277588, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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8
[SID103222736]
Ki 0.008Inhibition of Plasmodium falciparum ENR in presence of ECG [AID277600, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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9
[SID103222736]
Ki 0.00825Inhibition of Plasmodium falciparum ENR in presence of EGC [AID277599, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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10
[SID103222736]
Ki 0.01Inhibition of Plasmodium falciparum ENR in presence of quercetin [AID277601, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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11
[SID103222736]
Ki 0.01372Inhibition of Plasmodium falciparum ENR in presence of butein [AID277602, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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12
[SID103222736]
IC50 0.015Inhibition of Toxoplasma gondii enoyl reductase assessed as conversion of trans-2-acyl-ACP to acyl-ACP [AID741090, Type: Literature]Enoyl-acyl carrier reductase [gi:74837657]
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13
[SID103222736]
IC50 0.02Inhibition of Toxoplasma gondii enoyl reductase [AID509520, Type: Literature]
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14
[SID103222736]
Ki 0.02831Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of ECG [AID277589, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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15
[SID103222736]
Ki 0.03054Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of quercetin [AID277591, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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16
[SID103222736]
Ki 0.05Inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductase expressed in Escherichia coli BL21(DE3) by spectrophotometry [AID426408, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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17
[SID103222736]
Ki 0.05271Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of EGC [AID277590, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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18
[SID103222736]
IC50 0.059Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 mins [AID710143, Type: Literature]Trans-2-enoyl-ACP reductase [gi:75471646]
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19
[SID103222736]
IC50 0.066Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells [AID288442, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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20
[SID103222736]
IC50 0.07Inhibition of Plasmodium falciparum recombinant FabI [AID406448, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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21
[SID103222736]
IC50 0.07Inhibition of Plasmodium falciparum enoyl-ACP reductase assessed as oxidation of NADH to NAD+ after 10 mins by spectrophotometric analysis [AID638541, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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22
[SID103222736]
IC50 0.07Inhibitory activity against Enoyl-ACP reductase FabI in Staphylococcus aureus [AID67372, Type: Literature]
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23
[SID103222736]
IC50 0.07Concentration required for the 50% inhibition of enoyl-ACP reductase from Staphylococcus aureus was determined. [AID218918, Type: Literature]
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24
[SID103222736]
Ki 0.07102Inhibition of Plasmodium falciparum ENR by fluorescence quenching in presence of butein [AID277592, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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25
[SID103222736]
IC50 0.073Inhibition of Plasmodium falciparum ENR [AID326161, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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26
[SID103222736]
IC50 0.073Inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductase [AID426407, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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27
[SID103222736]
IC50 0.073Inhibition of Plasmodium falciparum ENR enzymatic activity [AID263605, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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28
[SID103222736]
IC50 0.073Inhibition of PfENR enzymatic activity [AID257396, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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29
[SID103222736]
IC50 0.17Inhibition of Escherichia coli FabI using crotonoyl-CoA as substrate preincubated for 90 mins [AID710149, Type: Literature]
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30
[SID103222736]
IC50 0.2Inhibition of Plasmodium falciparum Enoyl-ACP reductase using crotonyl-CoA as substrate peincubated for 5 mins measured after 10 mins of substrate addition by UV-vis spectrophotometry [AID611702, Type: Literature]Enoyl-ACP reductase [gi:74823252]
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31
[SID103222736]
Ki 0.2Inhibition of Mycobacterium tuberculosis H37RV InhA [AID319627, Type: Literature]Enoyl-[acyl-carrier-protein] reductase [NADH] [gi:61226660]
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32
[SID103222736]
Ki 0.232Inhibition of Plasmodium falciparum recombinant FabI A217V mutant [AID406451, Type: Literature]
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33
[SID57260157]
AC50_uM 0.329Bacterial Growth Inhibition Counterscreen using BacTiter-Glo Measured in Microorganism System Using Plate Reader - 2093-02_Inhibitor_Dose_CherryPick_Activity [AID504843, Type: confirmatory]
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34
[SID144214040]
Potency-Replicate_1 0.3518qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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35
[SID49674565]
IC50 0.369A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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36
[SID103222736]
IC50 0.4Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrate [AID347259, Type: Literature]Carbonyl reductase [NADPH] 1 [gi:118519]
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37
[SID103222736]
IC50 0.4244Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake [AID360366, Type: Literature]
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38
[SID103222736]
IC50 0.43Inhibitory activity against Enoyl-ACP reductase FabI in Escherichia coli [AID67370, Type: Literature]
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39
[SID103222736]
IC50 0.43Evaluated for inhibition of enoyl acyl carrier protein reductase (FabI) in Escherichia coli. [AID67361, Type: Literature]
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40
[SID103222736]
IC50 0.43Antibacterial activity against Escherichia coli FabI [AID67365, Type: Literature]
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41
[SID49674565]
IC50 0.49A Counter Screen to identiry small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID2401, Type: confirmatory]
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42
[SID103222736]
IC50 0.5Inhibition of Bacillus anthracis Enoyl ACP reductase [AID331275, Type: Literature]
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43
[SID103222736]
IC50 0.51Inhibition of Escherichia coli DH5-alpha His tagged Fab1 [AID284547, Type: Literature]
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44
[SID49674565]
IC50 0.55A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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45
[SID103222736]
Ki 0.66Inhibition of Plasmodium falciparum recombinant enoyl ACP reductase expressed in BL21 (DE3) cells with respect to crotonyl CoA [AID288443, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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46
[SID49674565]
IC50 0.67A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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47
[SID49674565]
IC50 0.68A screen for inhibitors of the PhoP regulon in Salmonella Typhimurium using a modified counterscreen. [AID1981, Type: confirmatory]
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48
[SID103222736]
IC50 0.7Antiparasitic activity against Plasmodium falciparum in RBCs [AID406449, Type: Literature]
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49
[SID103222736]
IC50 0.75Antibacterial activity against wild type Escherichia coli K12 after 12 hrs by microdilution method [AID408580, Type: Literature]
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50
[SID103222736]
IC50 0.7739Antimalarial activity after 48 hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake [AID360362, Type: Literature]
View