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Trazodone (CID 5533) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(36)
 
 
Inactive(307)
 
 
Inconclusive(28)
 
 
Unspecified(204)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
 
 
p450(26)
 
 
 
7TM GPCR Srsx(24)
 
 
 
 
HSD10-like SD..(8)
 
 
 
 
STKc ERK1 2 l..(5)
 
 
 
BioAssay Types:
Confirmatory(246)
 
 
 
 
Literature(156)
 
 
 
 
 
Screening(11)
 
 
BioActivity Types:
Potency(199)
 
 
 
 
IC50(120)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 408    Data Row: 575   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103188158]
IC50 0.017Compound was tested for the inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor [AID5482, Type: Literature]
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2
[SID103188158]
IC50 0.02DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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3
[SID103188158]
IC50 0.091DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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4
[SID103188158]
IC50 0.107DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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5
[SID103188158]
IC50 0.111DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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6
[SID103188158]
IC50 0.117DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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7
[SID103188158]
IC50 0.192DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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8
[SID103188158]
IC50 0.265DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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9
[SID103188158]
IC50 0.281Binding affinity by its ability to displace [3H]prazosin radioligand from Alpha-1 adrenergic receptor on rat cerebral cortex [AID36712, Type: Literature]
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10
[SID103188158]
IC50 0.281Compound was tested for the inhibition of [3H]-prazosin binding to Alpha-1 adrenergic receptor [AID36846, Type: Literature]
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11
[SID103188158]
IC50 0.311DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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12
[SID103188158]
IC50 0.361DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
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13
[SID103188158]
IC50 0.389DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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14
[SID103188158]
IC50 0.909DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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15
[SID103188158]
IC50 1.342DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: other]
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16
[SID103188158]
IC50 1.356DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: other]5-hydroxytryptamine receptor 1B [gi:112815]
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17
[SID103188158]
IC50 1.942DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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18
[SID103188158]
IC50 2.203DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: other]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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19
[SID103188158]
IC50 2.891DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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20
[SID103188158]
IC50 3.743DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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21
[SID11111901]
Potency 11.2202qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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22
[SID90341328]
Potency 11.2202HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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23
[SID11111901]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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24
[SID11111901]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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25
[SID11111900]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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26
[SID11111900]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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27
[SID135651275]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2B [AID624218, Type: Literature]5-hydroxytryptamine receptor 2B [Homo sapiens] [gi:222080049]
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28
[SID135651275]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2A [AID624223, Type: Literature]5-hydroxytryptamine receptor 2A isoform 2 [Homo sapiens] [gi:260099679]
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29
[SID135651275]
Antagonists at Human 5-Hydroxytryptamine receptor 5-HT2C [AID624209, Type: Literature]5-hydroxytryptamine receptor 2C isoform b precursor [Homo sapiens] [gi:377520139]
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30
[SID135651275]
Antagonists at Rat 5-Hydroxytryptamine receptor 5-HT2A [AID624222, Type: Literature]5-hydroxytryptamine receptor 2A [Rattus norvegicus] [gi:8393583]
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31
[SID135651275]
Antagonists at Rat 5-Hydroxytryptamine receptor 5-HT2C [AID624208, Type: Literature]5-hydroxytryptamine receptor 2C [Rattus norvegicus] [gi:17298688]
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32
[SID11111900]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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33
[SID11111900]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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34
[SID11111901]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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35
[SID11111901]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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36
[SID85209489]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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37
[SID11111901]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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38
[SID103188158]
Unbound fraction (plasma) [AID7783, Type: Literature]
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39
[SID103188158]
Observed volume of distribution [AID8002, Type: Literature]
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40
[SID103188158]
Calculated membrane partition coefficient (Kmemb) [AID19006, Type: Literature]
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41
[SID103188158]
Partition coefficient (logD7.4) [AID19424, Type: Literature]
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42
[SID103188158]
Delta logD (logD6.5 - logD7.4) [AID22293, Type: Literature]
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43
[SID103188158]
Partition coefficient (logD6.5) [AID26304, Type: Literature]
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44
[SID103188158]
Ionization constant (pKa) [AID26362, Type: Literature]
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45
[SID103188158]
Fraction ionized (pH 7.4) [AID28233, Type: Literature]
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46
[SID103188158]
Unbound fraction (plasma) [AID28235, Type: Literature]
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47
[SID103188158]
Unbound fraction (tissues) [AID28236, Type: Literature]
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48
[SID103188158]
Ionisation constant (pKa) [AID29337, Type: Literature]
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49
[SID103188158]
Ionization constant (pKa) [AID29359, Type: other]
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50
[SID103188158]
HPLC capacity factor (k') [AID29423, Type: other]
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