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Trazodone (CID 5533) - Compound BioActivity Data
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BioActivity Outcomes:
Active(39)
 
 
Inactive(308)
 
 
Inconclusive(28)
 
 
Unspecified(226)
 
 
Top Targets:
7tm 4(57)
 
 
 
 
 
p450(26)
 
 
 
HSD10-like SD..(8)
 
 
 
 
GH27(5)
 
 
CASc(5)
 
 
 
BioAssay Types:
Confirmatory(363)
 
 
 
 
 
Literature(184)
 
 
 
 
 
Screening(11)
 
 
BioActivity Types:
Potency(200)
 
 
 
 
IC50(120)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 431    Data Row: 601   Total Pages: 31   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103188158]
IC50 0.017Compound was tested for the inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor [AID5482, Type: Literature]
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2
[SID103188158]
IC50 0.02DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: confirmatory]5-hydroxytryptamine receptor 2A [gi:543727]
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3
[SID103188158]
IC50 0.091DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: confirmatory]5-hydroxytryptamine receptor 2C [gi:112816]
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4
[SID103188158]
IC50 0.107DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: confirmatory]5-hydroxytryptamine receptor 2B [gi:1168220]
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5
[SID103188158]
IC50 0.111DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: confirmatory]Alpha-1B adrenergic receptor [gi:543734]
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6
[SID103188158]
IC50 0.117DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168244]
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7
[SID103188158]
IC50 0.192DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: confirmatory]Sodium-dependent serotonin transporter [gi:400630]
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8
[SID103188158]
IC50 0.265DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168243]
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9
[SID103188158]
IC50 0.281Binding affinity by its ability to displace [3H]prazosin radioligand from Alpha-1 adrenergic receptor on rat cerebral cortex [AID36712, Type: Literature]
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10
[SID103188158]
IC50 0.281Compound was tested for the inhibition of [3H]-prazosin binding to Alpha-1 adrenergic receptor [AID36846, Type: Literature]
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11
[SID103188158]
IC50 0.311DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: confirmatory]
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12
[SID103188158]
IC50 0.361DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: confirmatory]Histamine H1 receptor [gi:547645]
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13
[SID103188158]
IC50 0.389DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:613504690]
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14
[SID103188158]
IC50 0.909DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: confirmatory]Alpha-2A adrenergic receptor [gi:1351829]
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15
[SID103188158]
IC50 1.342DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: confirmatory]
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16
[SID103188158]
IC50 1.356DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: confirmatory]5-hydroxytryptamine receptor 1B [gi:112815]
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17
[SID103188158]
IC50 1.942DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: confirmatory]Alpha-2C adrenergic receptor [gi:20141211]
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18
[SID103188158]
IC50 2.203DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: confirmatory]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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19
[SID103188158]
IC50 2.891DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: confirmatory]
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20
[SID103188158]
IC50 3.743DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: confirmatory]D(3) dopamine receptor [gi:1169206]
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