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VX680 (CID 5494449) - Compound BioActivity Data
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BioActivity Outcomes:
Active(840)
 
 
Inactive(662)
 
 
Inconclusive(15)
 
 
Unspecified(1280)
 
 
Top Targets:
PTKc Abl(37)
 
 
 
 
PKc like(34)
 
 
 
 
PTKc EGFR(23)
 
 
STKc RSK N(20)
 
 
 
 
7tm 4(20)
 
 
BioAssay Types:
Literature(1831)
 
 
 
 
 
Confirmatory(599)
 
 
 
 
 
Screening(354)
 
 
 
 
BioActivity Types:
Kd(774)
 
 
 
IC50(434)
 
 
 
 
 
Potency(68)
 
 
 
 
 
Ki(22)
 
 
EC50(7)
 
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2432    Data Row: 2797   Total Pages: 140   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103573134]
IC50 0.00024Inhibition of Aurora A by 33P minase hotspot assay [AID701395, Type: Literature]
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2
[SID103573134]
IC50 0.0006Inhibition of Aurora A [AID701397, Type: Literature]
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3
[SID103573134]
Ki 0.0006Inhibition of AURA [AID390094, Type: Literature]
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4
[SID103573134]
Ki 0.0006Inhibition of Aurora-A by coupled assay [AID420295, Type: Literature]
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5
[SID103573134]
Ki 0.0006In vitro inhibition constant for Aurora-A [AID273717, Type: Literature]Aurora kinase A [gi:27923855]
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6
[SID103573134]
IC50 0.0007Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cells [AID551679, Type: Literature]Aurora kinase A [gi:27923855]
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7
[SID103573134]
Ki 0.001Inhibition of Aurora A ATP-binding site [AID495140, Type: Literature]
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8
[SID103573134]
IC50 0.0014Inhibition of Aurora A [AID412579, Type: Literature]
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9
[SID103573134]
Ki 0.0018Inhibition of Aurora B kinase [AID316469, Type: Literature]
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10
[SID103573134]
Ki 0.0018Inhibition of Aurora-B by time dependent kinetic study [AID420311, Type: Literature]
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11
[SID103573134]
Ki 0.002Inhibition of phosphotransferase activity of recombinant aurora A expressed in HeLa cells [AID598117, Type: Literature]
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12
[SID103573134]
Kd 0.003Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID103573134]
Kd 0.0031Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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14
[SID103573134]
Kd 0.0033Binding constant for ABL1(H396P)-non phosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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15
[SID103573134]
IC50 0.00338SANGER: Inhibition of human BE-13 cell growth in a cell viability assay. [AID741975, Type: confirmatory]
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16
[SID103573134]
Kd 0.0038Binding constant for ABL1(Q252H)-non phosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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17
[SID103573134]
Kd 0.0039Binding constant for AURKA kinase domain [AID624919, Type: Literature]Aurora kinase A [gi:27923855]
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18
[SID103573134]
Kd 0.004Binding affinity to Aurora A kinase catalytic domain by competitive binding assay [AID616641, Type: Literature]
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19
[SID103573134]
Kd 0.004Binding affinity to Abl2 [AID353662, Type: Literature]
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20
[SID103573134]
Kd 0.004Binding constant for ABL2 kinase domain [AID435777, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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