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VX680 (CID 5494449) - Compound BioActivity Data
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BioActivity Outcomes:
Active(819)
 
 
Inactive(649)
 
 
Inconclusive(13)
 
 
Unspecified(1278)
 
 
Top Targets:
PKc(126)
 
 
 
 
PKc like(107)
 
 
 
 
STKc AGC(75)
 
 
 
 
PTKc Abl(35)
 
 
 
 
PTKc EGFR(23)
 
 
BioAssay Types:
Literature(1800)
 
 
 
 
 
Screening(353)
 
 
 
 
Confirmatory(237)
 
 
 
 
 
BioActivity Types:
Kd(772)
 
 
 
IC50(425)
 
 
 
 
 
Potency(63)
 
 
 
 
 
Ki(19)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2402    Data Row: 2759   Total Pages: 56   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103573134]
IC50 0.00024Inhibition of Aurora A by 33P minase hotspot assay [AID701395, Type: Literature]
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2
[SID103573134]
IC50 0.0006Inhibition of Aurora A [AID701397, Type: Literature]
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3
[SID103573134]
Ki 0.0006Inhibition of AURA [AID390094, Type: Literature]
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4
[SID103573134]
Ki 0.0006Inhibition of Aurora-A by coupled assay [AID420295, Type: Literature]
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5
[SID103573134]
Ki 0.0006In vitro inhibition constant for Aurora-A [AID273717, Type: Literature]Aurora kinase A [gi:27923855]
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6
[SID103573134]
IC50 0.0007Inhibition of human recombinant His-tagged Aurora A kinase expressed in insect cells [AID551679, Type: Literature]Aurora kinase A [gi:27923855]
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7
[SID103573134]
Ki 0.001Inhibition of Aurora A ATP-binding site [AID495140, Type: Literature]
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8
[SID103573134]
IC50 0.0014Inhibition of Aurora A [AID412579, Type: Literature]
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9
[SID103573134]
Ki 0.0018Inhibition of Aurora B kinase [AID316469, Type: Literature]
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10
[SID103573134]
Ki 0.0018Inhibition of Aurora-B by time dependent kinetic study [AID420311, Type: Literature]
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11
[SID103573134]
Ki 0.002Inhibition of phosphotransferase activity of recombinant aurora A expressed in HeLa cells [AID598117, Type: Literature]
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12
[SID103573134]
Kd 0.003Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID103573134]
Kd 0.0031Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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14
[SID103573134]
Kd 0.0033Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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15
[SID103573134]
IC50 0.00338SANGER: Inhibition of human BE-13 cell growth in a cell viability assay. [AID741975, Type: other]
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16
[SID103573134]
Kd 0.0038Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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17
[SID103573134]
Kd 0.0039Binding constant for AURKA kinase domain [AID624919, Type: Literature]Aurora kinase A [gi:27923855]
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18
[SID103573134]
Kd 0.004Binding affinity to Aurora A kinase catalytic domain by competitive binding assay [AID616641, Type: Literature]
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19
[SID103573134]
Kd 0.004Binding affinity to Abl2 [AID353662, Type: Literature]
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20
[SID103573134]
Kd 0.004Binding constant for ABL2 kinase domain [AID435777, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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21
[SID103573134]
Kd 0.004Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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22
[SID103573134]
IC50 0.00404SANGER: Inhibition of human RS4-11 cell growth in a cell viability assay. [AID741834, Type: other]
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23
[SID103573134]
Kd 0.0041Binding constant for AURKA kinase domain [AID435518, Type: Literature]Aurora kinase A [gi:27923855]
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24
[SID103573134]
Kd 0.0043Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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25
[SID103573134]
Kd 0.0043Binding constant for FLT3(N841I) kinase domain [AID435162, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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26
[SID103573134]
Ki 0.0046In vitro inhibition constant for Aurora-C [AID273719, Type: Literature]Aurora kinase C [gi:27805738]
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27
[SID103573134]
Ki 0.0046Inhibition of Aurora C [AID383104, Type: Literature]
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28
[SID103573134]
Ki 0.0046Inhibition of AURC [AID390096, Type: Literature]
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29
[SID103573134]
Ki 0.0046Inhibition of Aurora C kinase [AID316470, Type: Literature]
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30
[SID103573134]
Ki 0.0046Inhibition of aurora C [AID598126, Type: Literature]
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31
[SID103573134]
Kd 0.0048Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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32
[SID103573134]
Kd 0.0053Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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33
[SID103573134]
Kd 0.006Binding affinity to Aurora C kinase catalytic domain by competitive binding assay [AID616643, Type: Literature]
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34
[SID103573134]
IC50 0.006Inhibition of Aurora A [AID365842, Type: Literature]
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35
[SID103573134]
Kd 0.0063Binding constant for ABL1(T315I) kinase domain [AID435897, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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36
[SID103573134]
Kd 0.0063Binding constant for AURKC kinase domain [AID624769, Type: Literature]Aurora kinase C [gi:27805738]
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37
[SID103573134]
Kd 0.0063Binding constant for full-length AURKC [AID436006, Type: Literature]Aurora kinase C [gi:27805738]
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38
[SID103573134]
Kd 0.0065Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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39
[SID103573134]
Kd 0.0065Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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40
[SID103573134]
Kd 0.007Binding affinity to Aurora B kinase catalytic domain by competitive binding assay [AID616642, Type: Literature]
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41
[SID103573134]
Kd 0.0074Binding constant for AURKB kinase domain [AID435519, Type: Literature]Aurora kinase B [gi:317373473]
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42
[SID103573134]
Kd 0.0074Binding constant for AURKB kinase domain [AID624772, Type: Literature]Aurora kinase B [gi:317373473]
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43
[SID103573134]
Kd 0.0075Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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44
[SID103573134]
Kd 0.0078Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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45
[SID103573134]
Kd 0.0086Binding constant for RET(V804L) kinase domain [AID625123, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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46
[SID103573134]
Kd 0.009Binding affinity to Plk4 [AID353634, Type: Literature]
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47
[SID103573134]
Kd 0.0091Binding constant for ABL1(H396P) kinase domain [AID435146, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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48
[SID103573134]
Kd 0.0092Binding constant for PLK4 kinase domain [AID436044, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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49
[SID103573134]
Kd 0.0092Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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50
[SID103573134]
Kd 0.0093Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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