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norbinaltorphimine (CID 5480230) - Compound BioActivity Data
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BioActivity Outcomes:
Active(226)
 
 
Inactive(106)
 
 
Inconclusive(12)
 
 
Unspecified(133)
 
 
Top Targets:
7TM GPCR Srx(86)
 
 
 
 
7TM GPCR Srsx(34)
 
 
 
 
PIKKc TOR(4)
 
 
Pyr redox dim(4)
 
 
PLDc mTdp1 2(3)
 
 
BioAssay Types:
Literature(375)
 
 
 
 
Confirmatory(102)
 
 
 
 
BioActivity Types:
Ki(108)
 
 
Potency(100)
 
 
 
 
IC50(17)
 
 
EC50(6)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 455    Data Row: 477   Total Pages: 24   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103698780]
Ki 2.7e-05Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells [AID410720, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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2
[SID103698780]
Ki 3.8e-05Functional antagonism was obtained by the ability of compound to inhibit stimulation of [35S]GTP gamma S binding produced by selective agonists U69,593 in guinea pig caudate membranes [AID77794, Type: Literature]
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3
[SID103698780]
Ki 3.8e-05Inhibition of [35S]GTP-gamma-S, binding from Opioid receptor kappa 1 in Guinea pig Caudate stimulated by U69,593 [AID149428, Type: Literature]Kappa-type opioid receptor [gi:730228]
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4
[SID103698780]
Ki 3.8e-05Inhibition of stimulation of [35S]GTP-gamma-S, binding produced by the selective agonist (U69593, kappa-receptor), in guinea pig caudate membranes [AID149437, Type: Literature]Kappa-type opioid receptor [gi:730228]
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5
[SID103698780]
Ki 3.9e-05Compound was evaluated for its binding affinity by displacing [3H]U-69593 to human cloned Kappa opioid receptor transfected into CHO cells using [35S]GTP-gamma-S, assay [AID148016, Type: Literature]
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6
[SID103698780]
Ki 7e-05Antagonist activity on agonist (U50,488) stimulated [35S]GTP-gamma-S, binding in cloned opioid receptor kappa 1 [AID147989, Type: Literature]
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7
[SID103698780]
Ki 7e-05Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cells [AID148587, Type: Literature]
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8
[SID103698780]
Ki 0.00012Effect on binding affinity of mutational exchange of Glu297 in the Opioid receptor kappa 1 in transiently expressed rat cos-7 cells activity expressed as binding affinity. [AID148588, Type: Literature]
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9
[SID103698780]
Ki 0.00012Antagonist activity on agonist stimulated [35S]GTP-gamma-S, binding in guinea pig caudate membranes (10 uM U69,593 as the agonist ligand for kappa-receptor) [AID148990, Type: Literature]Kappa-type opioid receptor [gi:730228]
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10
[SID103698780]
Ki 0.00013Binding affinity using [3H]diprenorphine as the radioligand against wild-type Opioid receptor kappa 1 in COS-7 cells [AID148177, Type: Literature]
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11
[SID103698780]
Ki 0.000153Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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12
[SID103698780]
Ki 0.00019Displacement of [125I]-IBNalA from KOR-1 expressed in CHO cells [AID603175, Type: Literature]
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13
[SID103698780]
Ki 0.0002Compound was evaluated for its binding affinity to CHO cells expressing cloned human Opioid receptor kappa 1 by displacing [3H]U-69593 [AID148017, Type: Literature]
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14
[SID103698780]
Ki 0.0002Binding affinity towards human cloned Opioid receptor kappa 1 using [3H]U-69593 [AID148007, Type: Literature]
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15
[SID103698780]
Ki 0.0002Displacement of [3H]U-69593 from human recombinant Opioid receptor kappa 1 on CHO cell membranes. [AID147987, Type: Literature]
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16
[SID103698780]
Ki 0.0002Ability to displace [3H]U-69593 from human recombinant Opioid receptor kappa 1 in CHO cells [AID147988, Type: Literature]
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17
[SID103698780]
Ki 0.0002Binding affinity against cloned human Opioid receptor kappa 1 transfected into chinese hamster ovary cells using [3H]U-69593 as radioligand [AID148013, Type: Literature]
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18
[SID103698780]
Ki 0.0002Inhibition of [3H]U-69593 binding to human kappa opioid receptor expressed in CHO cells [AID239386, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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19
[SID103698780]
Ki 0.00023Displacement of [125I]-IBNtxA from KOR-1 expressed in CHO cells [AID603174, Type: Literature]
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20
[SID103698780]
Ki 0.00024Displacement of [3H]diprenorphine from delta-W284E-receptor expressed in HEK 293 cells [AID148583, Type: Literature]
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