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NSC357777 (CID 5477815) - Compound BioActivity Data
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BioActivity Outcomes:
Active(79)
 
 
Inactive(320)
 
 
Inconclusive(18)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(12)
 
 
 
p450(9)
 
 
 
Troponin(8)
 
 
 
CAP ED(5)
 
 
 
BioAssay Types:
Screening(228)
 
 
 
 
Confirmatory(162)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(116)
 
 
 
 
 
IC50(14)
 
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 366    Data Row: 419   Total Pages: 21   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4254263]
Potency 0.81Tau ThS binding assay [AID911, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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2
[SID4254263]
Potency 1.03Beta amyloid ThS binding assay [AID956, Type: confirmatory]beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa] [gi:257056]
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3
[SID4254263]
Potency 1.2589qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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4
[SID92763872]
AC50_uM 1.31MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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5
[SID92763872]
AC50_uM 2.15FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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6
[SID4254263]
Potency 2.62482Alpha-synuclein ThS binding assay [AID937, Type: confirmatory]alpha synuclein [Homo sapiens] [gi:46242542]
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7
[SID92763872]
IC50_Mean 5.61Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. [AID504756, Type: confirmatory]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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8
[SID92763872]
IC50 6.649Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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9
[SID92763872]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID92763872]
Potency 8.5683qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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11
[SID92763872]
IC50 8.598Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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12
[SID92763872]
IC50 8.598Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]troponin C, slow skeletal and cardiac muscles [Homo sapiens] [gi:4507615]
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13
[SID92763872]
IC50 8.598Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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14
[SID92763872]
IC50 8.598Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]troponin I, cardiac muscle [Homo sapiens] [gi:151101270]
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15
[SID92763872]
IC50_Mean 9.6Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay [AID588400, Type: confirmatory]phospholipase A2 precursor [Homo sapiens] [gi:4505847]
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16
[SID92763872]
Potency 11.2202qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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17
[SID92763872]
IC50 12.69Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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18
[SID92763872]
IC50 18.01Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Counter Screen Coupled Enzyme [AID624351, Type: confirmatory]
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19
[SID92763872]
Potency 19.1821qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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20
[SID92763872]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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