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KUC110309N (CID 54758532) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(1)
 
 
Top Targets:
Peptidase M17(2)
 
 
M1 APN 1(1)
 
 
PTZ00371(1)
 
 
BioAssay Types:
Confirmatory(6)
 
 
 
Screening(1)
 
 
BioActivity Types:
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 7   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID131485166]
Average HUM17LAP IC50 0.38Name: Counterscreen for inhibitors of PFM17LAP: QFRET-based biochemical high throughput dose response assay for inhibitors of the Human M17LAP (HUM17LAP) [AID602407, Type: confirmatory]leucine aminopeptidase [Homo sapiens] [gi:4335941]
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2
[SID131485166]
Average PFM17LAP IC50 2.27QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M17 Leucine Aminopeptidase (PFM17LAP) (3) [AID602309, Type: confirmatory]M17 leucyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23497510]
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3
[SID131485166]
Average PFM1AAP IC50 20.22Counterscreen for inhibitors of PFM17LAP: QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M1AAP (PFM1AAP) (3) [AID602315, Type: confirmatory]m1-family aminopeptidase [Plasmodium falciparum 3D7] [gi:23615263]
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4
[SID131485166]
Average PFM18AAP IC50 27.71Counterscreen for inhibitors of PFM17LAP: QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP) (3) [AID602316, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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5
[SID131485166]
Avg CC50 50Vero Cytoxicity Assay: A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Plasmodium falciparum M17 Leucine Aminopeptidase (PFM17LAP) (3) [AID602317, Type: confirmatory]
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6
[SID131485166]
Late stage assay provider results from the probe development effort to identify inhibitors of the Plasmodium falciparum M17 Leucine Aminopeptidase (M17LAP): radiolabel-based cell-based assay to identify compounds that inhibit P. falciparum growth in RBCs Set 2 [AID743274, Type: screening]
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7
[SID131485166]
IC50 16.3Late stage assay provider results from the probe development effort to identify inhibitors of the Plasmodium falciparum M17 Leucine Aminopeptidase (M17LAP): radiolabel-based cell-based dose response assay to identify compounds that inhibit P. falciparum growth in RBCs Set 2 [AID743273, Type: confirmatory]
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