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CHEMBL1834410 (CID 54756989) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(10)
 
 
 
BioAssay Types:
Literature(12)
 
 
 
BioActivity Types:
Ki(4)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 12    Data Row: 12   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134442154]
Ki 0.00127Displacement of [3H]Cl-DPDPE from human DOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621888, Type: Literature]Delta-type opioid receptor [gi:311033488]
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2
[SID134442154]
Ki 0.00159Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621889, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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3
[SID134442154]
EC50 0.0026Partial agonist activity at human MOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting [AID621021, Type: Literature]Mu-type opioid receptor [gi:2851402]
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4
[SID134442154]
Ki 0.00295Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621887, Type: Literature]Mu-type opioid receptor [gi:2851402]
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5
[SID134442154]
Ki 0.0185Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621019, Type: Literature]Nociceptin receptor [gi:730230]
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6
[SID134442154]
EC50 0.0501Partial agonist activity at human DOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting [AID621022, Type: Literature]Delta-type opioid receptor [gi:311033488]
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7
[SID134442154]
Partial agonist activity at human DOP receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting relative to DPDPE [AID621026, Type: Literature]Delta-type opioid receptor [gi:311033488]
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8
[SID134442154]
Partial agonist activity at human NOP receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting relative to nociceptin [AID621028, Type: Literature]Nociceptin receptor [gi:730230]
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9
[SID134442154]
Partial agonist activity at human KOP receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting relative to U69593 [AID621027, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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10
[SID134442154]
Selectivity ratio of Ki for human MOP receptor to Ki for human NOP receptor [AID621020, Type: Literature]
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11
[SID134442154]
Selectivity ratio of Ki for human NOP receptor to Ki for human MOP receptor [AID621037, Type: Literature]
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12
[SID134442154]
Partial agonist activity at human MOP receptor expressed in CHO cells assessed as maximal stimulation of [35S]GTPgammaS binding after 60 mins by scintillation counting relative to DAMGO [AID621025, Type: Literature]Mu-type opioid receptor [gi:2851402]
View