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N-alpha-(2-carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)ornithine amide (CID 54756938) - Compound BioActivity Data
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BioActivity Outcomes:
Active(21)
 
 
Inactive(4)
 
 
Inconclusive(3)
 
 
Unspecified(34)
 
 
Top Targets:
PAD(2)
 
 
BioAssay Types:
Literature(62)
 
 
 
 
 
BioActivity Types:
IC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 62    Data Row: 62   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136930637]
IC50 0.4Irreversible inhibition of PAD4 Q346A mutant assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins [AID627438, Type: Literature]
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2
[SID136930637]
IC50 1.1Irreversible inhibition of PAD4 Q346E mutant assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins [AID627437, Type: Literature]
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3
[SID136930637]
IC50 1.4Irreversible inhibition of PAD1 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluorometric analysis [AID627372, Type: Literature]
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4
[SID136930637]
IC50 1.9Irreversible inhibition of PAD4 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluorometric analysis [AID627371, Type: Literature]
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5
[SID136930637]
IC50 4.6Irreversible inhibition of PAD4 R374K mutant assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins [AID627439, Type: Literature]
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6
[SID136930637]
IC50 32Irreversible inhibition of PAD4 R374A mutant assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins [AID627440, Type: Literature]
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7
[SID136930637]
IC50 34Irreversible inhibition of PAD3 assessed as hydrolysis of benzoyl-L-arginine ethyl ester preincubated for 15 mins measured after 15 mins by fluorometric analysis [AID627374, Type: Literature]
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8
[SID136930637]
Irreversible inhibition of PAD1 assessed as residual activity at 1 mM measured after 20 hrs by colorimetric assay [AID627375, Type: Literature]
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9
[SID136930637]
Irreversible inhibition of PAD2 assessed as residual activity at 1 mM measured after 20 hrs by colorimetric assay [AID627426, Type: Literature]
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10
[SID136930637]
Irreversible inhibition of PAD3 assessed as residual activity at 1 mM measured after 20 hrs by colorimetric assay [AID627427, Type: Literature]
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11
[SID136930637]
Irreversible inhibition of PAD4 assessed as residual activity at 1 mM measured after 20 hrs by colorimetric assay [AID627428, Type: Literature]
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12
[SID136930637]
Induction of human HL60 cell differentiation assessed as increase in PAD4 expression level at 10 uM after 6 hrs by Western blotting [AID627446, Type: Literature]
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13
[SID136930637]
Induction of human HL60 cell differentiation assessed as increase in PAD4 expression level at 1 uM after 12 hrs by Western blotting [AID627447, Type: Literature]
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14
[SID136930637]
Induction of human HL60 cell differentiation assessed as increase in PAD4 expression level at 1 uM after 24 hrs by Western blotting [AID627448, Type: Literature]
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15
[SID136930637]
Inhibition of PAD4 in calcium ionophore A23187 stimulated-human HL60 granulocytes assessed as reduction in deaminated histone H3 at 1 uM after 30 mins by Western blotting [AID627442, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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16
[SID136930637]
Inhibition of PAD4 in calcium ionophore A23187 stimulated-human HL60 granulocytes assessed as reduction in deaminated histone H3 at 100 uM after 48 hrs by Western blotting [AID627443, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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17
[SID136930637]
Irreversible inhibition of PAD1 assessed as citrulline formation at 1 mM measured after 20 hrs by colorimetric assay in presence of 2 mM benzoyl-L-arginine ethyl ester [AID626681, Type: Literature]
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18
[SID136930637]
Irreversible inhibition of PAD2 assessed as residual activity at 1 mM measured after 20 hrs by colorimetric assay in presence of 2 mM benzoyl-L-arginine ethyl ester [AID626722, Type: Literature]
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19
[SID136930637]
Irreversible inhibition of PAD3 assessed as residual activity at 1 mM measured after 20 hrs by colorimetric assay in presence of 2 mM benzoyl-L-arginine ethyl ester [AID626723, Type: Literature]
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20
[SID136930637]
Irreversible inhibition of PAD4 assessed as residual activity at 1 mM measured after 20 hrs by colorimetric assay in presence of 2 mM benzoyl-L-arginine ethyl ester [AID626724, Type: Literature]
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