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MLS002154117 (CID 54736625) - Compound BioActivity Data
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BioActivity Outcomes:
Active(103)
 
 
Inactive(279)
 
 
Inconclusive(31)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(12)
 
 
 
 
zf-Tim10 DDP(5)
 
 
 
B zip1(5)
 
 
 
Bcl-2 like(5)
 
 
 
BioAssay Types:
Screening(283)
 
 
 
 
Confirmatory(122)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(100)
 
 
 
 
 
IC50(17)
 
 
 
 
AC50(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 377    Data Row: 414   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56463155]
Potency 0.0033Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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2
[SID56463155]
Potency 0.0366qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID56463155]
Potency 0.1458qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID56463155]
Potency 0.2617Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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5
[SID56463155]
Potency 0.92qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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6
[SID56463155]
Potency 1qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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7
[SID56463155]
Potency 1.1582Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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8
[SID56463155]
Potency 1.2995Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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9
[SID56463155]
Potency 1.4581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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10
[SID56463155]
IC50 1.86High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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11
[SID56463155]
Potency 1.9953qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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12
[SID56463155]
CC50 2.278A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
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13
[SID56463155]
Potency 3.1623qHTS for Inhibitors of Vif-A3F Interactions: qHTS [AID602313, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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14
[SID56463155]
IC50 3.26A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
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15
[SID56463155]
IC50_Mean 3.92Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent TIM10 yeast counterscreen [AID504542, Type: confirmatory]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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16
[SID56463155]
Potency 3.9811qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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17
[SID56463155]
AC50_uM 4.394Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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18
[SID56463155]
EC50 4.95A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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19
[SID56463155]
Potency 5.8048Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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20
[SID56463155]
AC50_uM 5.905HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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21
[SID56463155]
IC50_Mean 5.95Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. [AID504544, Type: confirmatory]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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22
[SID56463155]
Potency 7.0795qHTS for Inhibitors of Vif-A3G Interactions: qHTS [AID602310, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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23
[SID56463155]
Potency 7.3078Nrf2 qHTS screen for inhibitors: A549 ARE-Fluc Cytotoxicity Counterscreen for Hit Validation [AID720523, Type: confirmatory]
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24
[SID56463155]
IC50_Mean 9.45Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID493003, Type: confirmatory]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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25
[SID56463155]
Potency 12.5893qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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26
[SID56463155]
Potency 12.5893qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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27
[SID56463155]
IC50 21.73A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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28
[SID56463155]
IC50 27.76A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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29
[SID56463155]
Potency 31.6228qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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30
[SID56463155]
IC50 32.032A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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31
[SID56463155]
Potency 50.1187qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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32
[SID56463155]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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33
[SID56463155]
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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34
[SID56463155]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of human diacylglycerol lipase, beta (DAGLB) [AID504411, Type: screening]sn1-specific diacylglycerol lipase beta isoform 1 [Homo sapiens] [gi:218931251]
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35
[SID56463155]
Fluorescence-based biochemical high throughput confirmation assay for inhibitors of human diacylglycerol lipase, beta (DAGLB) [AID504445, Type: screening]sn1-specific diacylglycerol lipase beta isoform 1 [Homo sapiens] [gi:218931251]
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36
[SID56463155]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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37
[SID56463155]
Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling [AID588676, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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38
[SID56463155]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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39
[SID56463155]
FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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40
[SID56463155]
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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41
[SID56463155]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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42
[SID56463155]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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43
[SID56463155]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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44
[SID56463155]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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45
[SID56463155]
Fluorescence polarization-based cell-based high throughput confirmation assay for inhibitors of insulin-degrading enzyme (IDE) [AID435028, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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46
[SID56463155]
uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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47
[SID56463155]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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48
[SID56463155]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]perilipin-5 [Homo sapiens] [gi:116292172]
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49
[SID56463155]
Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID504621, Type: screening]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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50
[SID56463155]
RNA aptamer-based HTS for inhibitors of GRK2 [AID488847, Type: screening]beta-adrenergic receptor kinase 1 [Homo sapiens] [gi:148539876]
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