CHEMBL464651 (CID 54726845) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(4)
 
 
Unspecified(2)
 
 
Top Targets:
Neur chan LBD(7)
 
 
 
 
BioAssay Types:
Literature(7)
 
 
 
 
BioActivity Types:
EC50(1)
 
 
IC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 9   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103600709]
EC50 1.2Agonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as potentiation of glycine current by whole cell patch clamp assay [AID474942, Type: Literature]Glycine receptor subunit alpha-1 [gi:116242495]
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2
[SID103600709]
IC50 7Antagonist activity at human recombinant alpha 3 GlyR expressed in HEK293 cells assessed as inhibition of glycine current influx by whole cell patch clamp assay [AID474949, Type: Literature]Glycine receptor subunit alpha-3 [gi:116242496]
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3
[SID103600709]
 Antagonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as inhibition of glycine current influx up to 30 uM by whole cell patch clamp assay [AID472422, Type: Literature]Glycine receptor subunit alpha-1 [gi:116242495]
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4
[SID103600709]
 Antagonist activity at human recombinant alpha 2 GlyR expressed in HEK293 cells assessed as inhibition of glycine current influx at 10 uM by whole cell patch clamp assay [AID472420, Type: Literature]Glycine receptor subunit alpha-2 [gi:121578]
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5
[SID103600709]
 Agonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as potentiation of glycine current at 100 uM by whole cell patch clamp assay relative to EC20 glycine maximum response [AID474943, Type: Literature]Glycine receptor subunit alpha-1 [gi:116242495]
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6
[SID103600709]
 Antagonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as inhibition of glycine current influx by whole cell patch clamp assay [AID474948, Type: Literature]Glycine receptor subunit alpha-1 [gi:116242495]
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7
[SID103600709]
 Antiviral activity against Poliovirus type 1 infected in rat BSC cells at 20 ug/disk [AID334954, Type: other]
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8
[SID103600709]
 Antiviral activity against HSV1 infected in rat BSC cells at 20 ug/disk [AID334953, Type: other]
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9
[SID103600709]
 Agonist activity at human recombinant alpha 3 GlyR expressed in HEK293 cells assessed as potentiation of glycine current by whole cell patch clamp assay [AID474945, Type: Literature]Glycine receptor subunit alpha-3 [gi:116242496]
View