N-cycloheptyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide (CID 54713096) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(11)
 
 
Inactive(716)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
alkPPc(16)
 
 
Tryp SPc(12)
 
 
Bcl-2 like(11)
 
 
7TM GPCR Srsx(10)
 
 
BioAssay Types:
Screening(488)
 
 
 
 
Confirmatory(225)
 
 
 
 
 
Literature(7)
 
 
BioActivity Types:
Potency(147)
 
 
 
 
 
IC50(44)
 
 
EC50(11)
 
 
AC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 743    Data Row: 743   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID846832]
Potency 1qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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2
[SID846832]
AbsAC40_uM 1.096MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_Dose_CherryPick_Activity [AID540258, Type: confirmatory]
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3
[SID846832]
Potency 2.6855qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID846832]
AC50 62.686MITF Act Counter Assay: HeLa CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-08_Activator_Dose_CherryPick_Activity [AID540259, Type: confirmatory]
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5
[SID846832]
 MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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6
[SID846832]
 Glucocerebrosidase [AID360, Type: confirmatory]Chain A, X-Ray Structure Of Human Acid-Beta-Glucosidase Covalently Bound To Conduritol B Epoxide [gi:66360678]
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7
[SID846832]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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8
[SID846832]
 Primary cell-based high throughput screening assay to measure STAT1 activation [AID932, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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9
[SID846832]
 Primary cell-based high throughput screening assay to measure STAT1 activation [AID932, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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10
[SID846832]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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11
[SID846832]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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12
[SID846832]
 Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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13
[SID846832]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID846832]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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15
[SID846832]
Potency 1.0399qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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16
[SID846832]
Potency 1.122qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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17
[SID846832]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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18
[SID846832]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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19
[SID846832]
 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary Screen [AID628, Type: screening]Muscarinic acetylcholine receptor M [gi:113121]
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20
[SID846832]
 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary Screen [AID628, Type: screening]Muscarinic acetylcholine receptor M [gi:113121]
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21
[SID846832]
 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary Screen [AID628, Type: screening]Muscarinic acetylcholine receptor M [gi:113121]
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22
[SID846832]
 Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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23
[SID846832]
 Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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24
[SID846832]
 Kallikrein 5 1536 HTS [AID873, Type: screening]kallikrein-related peptidase 5 preproprotein [Homo sapiens] [gi:6912644]
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25
[SID846832]
 Kallikrein 5 1536 HTS [AID873, Type: screening]kallikrein-related peptidase 5 preproprotein [Homo sapiens] [gi:6912644]
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26
[SID846832]
Potency qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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27
[SID846832]
Potency qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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28
[SID846832]
 uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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29
[SID846832]
IC50 uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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30
[SID846832]
IC50 uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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31
[SID846832]
IC50 uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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32
[SID846832]
 LYP Activators-an Autoimmunity Target - Primary screen [AID697, Type: screening]PTPN22 gene product [Homo sapiens] [gi:224586929]
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33
[SID846832]
 LYP Activators-an Autoimmunity Target - Primary screen [AID697, Type: screening]PTPN22 gene product [Homo sapiens] [gi:224586929]
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34
[SID846832]
 LYP Activators-an Autoimmunity Target - Primary screen [AID697, Type: screening]PTPN22 gene product [Homo sapiens] [gi:224586929]
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35
[SID846832]
 LYP Inhibitors-an Autoimmunity Target - Primary screen [AID640, Type: screening]PTPN22 gene product [Homo sapiens] [gi:224586929]
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36
[SID846832]
 LYP Inhibitors-an Autoimmunity Target - Primary screen [AID640, Type: screening]PTPN22 gene product [Homo sapiens] [gi:224586929]
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37
[SID846832]
 LYP Inhibitors-an Autoimmunity Target - Primary screen [AID640, Type: screening]PTPN22 gene product [Homo sapiens] [gi:224586929]
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38
[SID846832]
 HTS for LYP Inhibitors-an Autoimmunity Target - Primary screen [AID606, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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39
[SID846832]
 HTS for LYP Inhibitors-an Autoimmunity Target - Primary screen [AID606, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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40
[SID846832]
 HTS for LYP Inhibitors-an Autoimmunity Target - Primary screen [AID606, Type: confirmatory]PTPN22 gene product [Homo sapiens] [gi:224586929]
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41
[SID846832]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) [AID2014, Type: confirmatory]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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42
[SID846832]
 uHTS identification of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay [AID588489, Type: screening]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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43
[SID846832]
IC50 Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]RACGAP1 gene product [Homo sapiens] [gi:21361397]
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44
[SID846832]
Potency qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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45
[SID846832]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]ASAP1 gene product [Homo sapiens] [gi:351542238]
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46
[SID846832]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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47
[SID846832]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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48
[SID846832]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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49
[SID846832]
 Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9 [AID488922, Type: screening]KCNK9 gene product [Homo sapiens] [gi:7706135]
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50
[SID124782793]
 A screen for small molecule inhibitors of the human deubiquitinating enzyme, UCH37 [AID588478, Type: other]ubiquitin C-terminal hydrolase UCH37 [Homo sapiens] [gi:4877999]
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