MLS003115579 (CID 54711397) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(155)
 
 
Inconclusive(3)
 
 
Unspecified(8)
 
 
Top Targets:
Death TRAILR..(12)
 
 
 
 
7TM GPCR Srx(8)
 
 
7TM GPCR Srsx(4)
 
 
Herpes LMP1(4)
 
 
 
CRF-BP(2)
 
 
BioAssay Types:
Screening(132)
 
 
 
 
Confirmatory(37)
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(30)
 
 
 
 
AC50(4)
 
 
 
IC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 165    Data Row: 175   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99360873]
AC50 6.16Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity [AID588343, Type: confirmatory]
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2
[SID99360873]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID99360873]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID99360873]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID99360873]
 Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity [AID504558, Type: screening]LMP1 [Human herpesvirus 4] [gi:23893668]
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6
[SID99360873]
 Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA) [AID651718, Type: screening]MSRA protein [Bos taurus] [gi:73586699]
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7
[SID99360873]
 Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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8
[SID99360873]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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9
[SID99360873]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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10
[SID99360873]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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11
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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12
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
13
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
14
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
15
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_3, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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16
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_3, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
17
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_4, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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18
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_4, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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19
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_5, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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20
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_5, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
21
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_2, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
22
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_2, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
23
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_7, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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24
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_7, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
25
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_8, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
26
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_8, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
27
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_9, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
28
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_9, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
29
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_10, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
30
[SID99360873]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_10, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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31
[SID99360873]
Potency 11.2202qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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32
[SID99360873]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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33
[SID99360873]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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34
[SID99360873]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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35
[SID99360873]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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36
[SID99360873]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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37
[SID99360873]
Potency qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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38
[SID99360873]
Potency qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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39
[SID99360873]
Potency qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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40
[SID99360873]
Potency qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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41
[SID99360873]
Potency qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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42
[SID99360873]
 TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4R [AID540295, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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43
[SID99360873]
 TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4R [AID540295, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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44
[SID99360873]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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45
[SID99360873]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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46
[SID99360873]
 Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]MLLT3 gene product [Homo sapiens] [gi:156104889]
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47
[SID99360873]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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48
[SID99360873]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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49
[SID99360873]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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50
[SID99360873]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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