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AC1NTE6Y (CID 54707106) - Compound BioActivity Data
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BioActivity Outcomes:
Active(39)
 
 
Inactive(575)
 
 
Inconclusive(37)
 
 
Unspecified(1)
 
 
Top Targets:
TRP 2(23)
 
 
 
7TM GPCR Srx(22)
 
 
 
7TM GPCR Srsx(17)
 
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Screening(450)
 
 
 
 
Confirmatory(191)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(137)
 
 
 
 
 
IC50(38)
 
 
 
 
EC50(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 598    Data Row: 652   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24815104]
Potency 0.7079Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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2
[SID24815104]
EC50 0.726HCS for Compounds that Up-Regulate Insulin Promoter Activity in MIN6 Cells [AID1625, Type: confirmatory]
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3
[SID24815104]
Potency 1.2995qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen [AID651813, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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4
[SID24815104]
Potency 1.4581qHTS for inhibitors of Vif-A3F interactions: Cherry picks [AID651814, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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5
[SID24815104]
Potency 1.4581qHTS for inhibitors of Vif-A3G interactions: Cherry picks [AID651812, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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6
[SID24815104]
IC50 2.072Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE) [AID463220, Type: confirmatory]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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7
[SID24815104]
Potency 4.1095qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen [AID651815, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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8
[SID24815104]
EC50 7.4973Confirmation dose response assay for compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID434937, Type: confirmatory]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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9
[SID24815104]
Potency 21.3313qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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10
[SID24815104]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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11
[SID24815104]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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12
[SID24815104]
Primary cell-based screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID2237, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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13
[SID24815104]
Confirmatory screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID2426, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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14
[SID24815104]
Specificity screen against TRPC4 for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488927, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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15
[SID24815104]
Second specificity screen against TRPC4 for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488928, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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16
[SID24815104]
Second counter screen for compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID434977, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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17
[SID24815104]
Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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18
[SID24815104]
HTS Assay for Allosteric Agonists of the Human D2 Dopamine Receptor: Primary Screen for Agonists [AID485358, Type: screening]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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19
[SID24815104]
qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Primary Screen for Agonists. [AID493084, Type: screening]thyrotropin-releasing hormone receptor [Homo sapiens] [gi:4507681]
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20
[SID24815104]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin C, slow skeletal and cardiac muscles [Homo sapiens] [gi:4507615]
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21
[SID24815104]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624037, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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22
[SID24815104]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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23
[SID24815104]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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24
[SID24815104]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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25
[SID24815104]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
View
26
[SID24815104]
Fluorescence polarization-based cell-based high throughput confirmation assay for inhibitors of insulin-degrading enzyme (IDE) [AID435028, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
View
27
[SID24815104]
High throughput screening of activators of transient receptor potential cation channel C6 (TRPC6) [AID2550, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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28
[SID24815104]
Flow Cytometric HTS singleplex for inhibitors of yeast efflux pump, specifically Cdr2 with Cherry Pick1 compound set [AID588520, Type: screening]drug resistance protein 2 [Candida albicans] [gi:93115982]
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29
[SID24815104]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin I, cardiac muscle [Homo sapiens] [gi:151101270]
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30
[SID24815104]
Confirmatory screen for identification of compounds that activate transient receptor potential cation channel C6 (TRPC6) [AID488961, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
View
31
[SID24815104]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID1962, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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32
[SID24815104]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID2149, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
View
33
[SID24815104]
Fluorescence polarization-based counterscreen assay for inhibitors of tRNA 2'-phosphotransferase (TPT1): biochemical high throughput screening assay to identify inhibitors of RNAse T1. [AID2153, Type: screening]unnamed protein product [Aspergillus oryzae RIB40] [gi:83774548]
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34
[SID24815104]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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35
[SID24815104]
Counter screen for compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID449723, Type: screening]
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36
[SID24815104]
Specificity screen against TRPC6 for compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID434950, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
View
37
[SID24815104]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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38
[SID24815104]
Counter screen for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488924, Type: screening]
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39
[SID24815104]
Second counter screen for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488926, Type: screening]
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40
[SID24815104]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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41
[SID24815104]
Potency 4.4668qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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42
[SID24815104]
Potency 5.0119qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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43
[SID24815104]
Potency 6.5733Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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44
[SID24815104]
Potency 11.2202qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction [AID624246, Type: confirmatory]transcriptional regulator ERG isoform 3 [Homo sapiens] [gi:343478176]
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45
[SID24815104]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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46
[SID24815104]
EC50 16Counterscreen for Fluorescence in GFP-Spectra Wavelengths Caused By Cell-Permeable Autofluorescent Compounds [AID2124, Type: confirmatory]
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47
[SID24815104]
EC50 19.5016Image-based HTS for Selective Agonists of GPR55 [AID1961, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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48
[SID24815104]
Potency 28.1838qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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49
[SID24815104]
IC50 55.694Counterscreen for IDE inhibitors: Luminescence-based cell-based high throughput dose response assay to identify compounds that are cytotoxic to HEK cells [AID463221, Type: confirmatory]
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50
[SID24815104]
IC50 High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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