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CHEMBL1097558 (CID 54704052) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(66)
 
 
Inconclusive(43)
 
 
Unspecified(308)
 
 
Top Targets:
7tm 4(33)
 
 
 
p450(10)
 
 
 
 
NR LBD ER(9)
 
 
 
 
 
NR LBD PPAR(8)
 
 
NR LBD AR(8)
 
 
 
 
BioAssay Types:
Confirmatory(208)
 
 
 
 
 
Literature(28)
 
 
 
Summary(24)
 
 
 
 
Screening(7)
 
 
BioActivity Types:
IC50(124)
 
 
 
Potency(110)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 437    Data Row: 443   Total Pages: 23   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103749862]
IC50 0.01In vitro inhibition of Prostaglandin G/H synthase pathway in rat basophilic leukemia (RBL-1) cells [AID160880, Type: Literature]
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2
[SID103749862]
IC50 0.053In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells. [AID228173, Type: Literature]
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3
[SID103749862]
IC50 0.055DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:317373262]
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4
[SID103749862]
IC50 0.267DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) [AID625244, Type: confirmatory]Prostaglandin G/H synthase 2 [gi:3915797]
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5
[SID103749862]
IC50 0.7DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: confirmatory]Cytochrome P450 2C9 [gi:6686268]
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6
[SID103749862]
IC50 1DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: confirmatory]Cytochrome P450 1A2 [gi:117144]
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7
[SID103749862]
IC50 2.56Inhibition of COX-1 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs by HPLC in presence of calcium ionophore A23187 [AID539315, Type: Literature]Prostaglandin G/H synthase 1 [gi:75039091]
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8
[SID144205310]
Potency-Replicate_1 5.9557qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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9
[SID103749862]
IC50 8.4Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of calcium ionophore A23188 and lipopolysaccharide [AID539314, Type: Literature]
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10
[SID144205310]
Potency-Replicate_1 8.4127qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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11
[SID103749862]
IC50 9In vitro inhibition of 5-lipoxygenase pathway in rat basophilic leukemia (RBL-1) cells [AID6824, Type: Literature]
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12
[SID144205310]
Potency-Replicate_1 11.8832qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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13
[SID144205310]
Ratio Potency (uM) 12.533qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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14
[SID144205310]
Ratio Potency (uM) 14.9601qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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15
[SID103749862]
IC50 16In vitro effect on production of lipopolysaccharide (LPS) -induced IL1-beta in human THP-1 cells [AID221973, Type: Literature]
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16
[SID144205310]
Potency-Replicate_1 21.3138qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID144205310]
Ratio Potency (uM) 21.3138qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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18
[SID144205310]
Potency-Replicate_1 23.7101qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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19
[SID144205310]
AhR Potency (uM) 26.6032qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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20
[SID144205310]
Potency-Replicate_1 29.8493qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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