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AC1NXPBU (CID 54690845) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(821)
 
 
Inconclusive(12)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(557)
 
 
 
 
Confirmatory(256)
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(168)
 
 
 
 
IC50(51)
 
 
EC50(10)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 772    Data Row: 838   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID852467]
HTS for BAP1 Enzyme inhibitors [AID436, Type: screening]Ubiquitin carboxyl-terminal hydrolase BAP1 [gi:68565074]
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2
[SID852467]
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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3
[SID852467]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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4
[SID852467]
Screen for Chemicals that Extend Yeast Lifespan [AID775, Type: screening]
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5
[SID852467]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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6
[SID852467]
Potency 0.7943qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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7
[SID852467]
Potency 0.8913qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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8
[SID852467]
Potency 1qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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9
[SID852467]
Potency 7.3753Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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10
[SID852467]
IL-1B Induced NFkB Translocation - Primary Screen [AID796, Type: screening]
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11
[SID852467]
Cell signaling CRE-BLA (Fsk stim) [AID662, Type: confirmatory]
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12
[SID852467]
Profiling the NIH Molecular Libraries Small Molecule Repository: Absorbance at 340 nm [AID708, Type: screening]
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13
[SID852467]
Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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14
[SID852467]
Antimicrobial HTS Assay for E. coli BW25113 (wild type) - Expanded Screen [AID710, Type: screening]
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15
[SID852467]
Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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16
[SID852467]
Screening for Modulators of Post-Golgi Transport, Control Strain [AID738, Type: screening]
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17
[SID852467]
qHTS Assay for Inhibitors of DNA Polymerase III Holoenzyme System [AID603, Type: confirmatory]
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18
[SID852467]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HT1080 cells) [AID620, Type: confirmatory]
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19
[SID852467]
Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [AID626, Type: screening]
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20
[SID852467]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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21
[SID852467]
Isolation of Inhibitors of Her-Kinase Expression - 66K library screen [AID645, Type: screening]
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22
[SID852467]
Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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23
[SID852467]
qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral Region [AID593, Type: other]
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24
[SID852467]
qHTS Assay for Spectroscopic Profiling in Rhodamine Spectral Region [AID594, Type: confirmatory]
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25
[SID852467]
qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction [AID595, Type: confirmatory]
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26
[SID852467]
qHTS Assay for Epigenetic Modulators [AID597, Type: confirmatory]
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27
[SID852467]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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28
[SID852467]
Identification of Molecular Probes that Reverse MRP-Mediated Drug Resistance [AID602, Type: screening]
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29
[SID852467]
qHTS Assay for Spectroscopic Profiling in Texas Red Spectral Region [AID587, Type: other]
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30
[SID852467]
qHTS Assay for Spectroscopic Profiling in Resorufin Spectral Region [AID588, Type: other]
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31
[SID852467]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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32
[SID852467]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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33
[SID852467]
qHTS Assay for Spectroscopic Profiling in A488 Spectral Region [AID591, Type: other]
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34
[SID852467]
qHTS Assay for Spectroscopic Profiling in A647 Spectral Region [AID592, Type: other]
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35
[SID852467]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]LuxS [Vibrio harveyi] [gi:166202459]
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36
[SID852467]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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37
[SID852467]
uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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38
[SID852467]
Potency HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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39
[SID852467]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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40
[SID852467]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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41
[SID852467]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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42
[SID852467]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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43
[SID852467]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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44
[SID852467]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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45
[SID852467]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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46
[SID852467]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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47
[SID852467]
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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48
[SID852467]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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49
[SID852467]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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50
[SID852467]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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