Ambcb5118569 (CID 54690450) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(25)
 
 
Inactive(577)
 
 
Inconclusive(32)
 
 
Unspecified(10)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
alkPPc(12)
 
 
Death TRAILR..(12)
 
 
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(8)
 
 
BioAssay Types:
Screening(446)
 
 
 
 
 
Confirmatory(183)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(131)
 
 
 
 
 
IC50(39)
 
 
 
 
EC50(8)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 634    Data Row: 644   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14734586]
Potency 1.3459qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID14734586]
Potency 1.7783qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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3
[SID14734586]
Potency 3.5481qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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4
[SID14734586]
Potency 11.2202qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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5
[SID14734586]
Potency 14.1254qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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6
[SID14734586]
Potency 16.3601qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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7
[SID14734586]
 Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID2149, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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8
[SID14734586]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID1962, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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9
[SID14734586]
 Fluorescence polarization-based counterscreen assay for inhibitors of tRNA 2'-phosphotransferase (TPT1): biochemical high throughput screening assay to identify inhibitors of RNAse T1. [AID2153, Type: screening]unnamed protein product [Aspergillus oryzae] [gi:83774548]
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10
[SID14734586]
 Fluorescence polarization-based counterscreen assay for inhibitors of tRNA 2'-phosphotransferase (TPT1): biochemical high throughput screening assay to identify inhibitors of RNAse T1. [AID2153, Type: screening]unnamed protein product [Aspergillus oryzae] [gi:83774548]
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11
[SID14734586]
 uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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12
[SID14734586]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]Il2 gene product [Mus musculus] [gi:7110653]
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13
[SID14734586]
 Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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14
[SID14734586]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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15
[SID14734586]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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16
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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17
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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18
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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19
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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20
[SID14734586]
 uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells [AID1443, Type: screening]tumor necrosis factor ligand superfamily member 10 isoform 1 [Homo sapiens] [gi:4507593]
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21
[SID14734586]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) [AID2014, Type: confirmatory]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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22
[SID14734586]
 Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
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23
[SID14734586]
 Identification of compounds which are cytotoxic to PPC-1 cells. [AID1447, Type: screening]
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24
[SID14734586]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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25
[SID14734586]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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26
[SID14734586]
 Primary biochemical high-throughput screening assay for inhibitors of the HIV Rev RRE RNA interaction (disruption of protein-RNA interaction) [AID704, Type: screening]Chain B, Rna Aptamer Complexed With Hiv-1 Rev Peptide, Nmr, 7 Structures [gi:253722402]
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27
[SID14734586]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
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28
[SID14734586]
 High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary Screen [AID1239, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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29
[SID14734586]
 High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary Screen [AID1239, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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30
[SID14734586]
 High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary Screen [AID1239, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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31
[SID14734586]
 High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary Screen [AID1239, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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32
[SID14734586]
 Primary cell-based high throughput screening assay to measure STAT1 activation [AID932, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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33
[SID14734586]
 Primary cell-based high throughput screening assay to measure STAT1 activation [AID932, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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34
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_2, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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35
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_2, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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36
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_3, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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37
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_3, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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38
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_7, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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39
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_7, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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40
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_8, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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41
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_8, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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42
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_9, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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43
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_9, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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44
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_10, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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45
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_10, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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46
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_4, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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47
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_4, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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48
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_5, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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49
[SID14734586]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_5, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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50
[SID14734586]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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