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4-hydroxy-1-methyl-N-(4-methylpyridin-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide (CID 54690402) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(254)
 
 
Inconclusive(10)
 
 
Top Targets:
alkPPc(12)
 
 
7TM GPCR Srx(10)
 
 
7TM GPCR Srsx(6)
 
 
Tryp SPc(6)
 
 
Pyruvate Kina..(5)
 
 
BioAssay Types:
Confirmatory(161)
 
 
 
 
Screening(105)
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(97)
 
 
 
 
IC50(34)
 
 
EC50(11)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 260    Data Row: 276   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID844951]
Potency 3.0131qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID844951]
Potency 3.5481qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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3
[SID844951]
Potency 3.9811qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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4
[SID844951]
Potency 12.5893qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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5
[SID844951]
Primary Cell-based High Throughput Screening assay for activators of the Retinoic Acid Receptor-related orphan receptor A (RORA) [AID560, Type: screening]Nuclear receptor ROR-alpha [gi:548814]
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6
[SID844951]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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7
[SID844951]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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8
[SID844951]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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9
[SID844951]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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10
[SID844951]
HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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11
[SID844951]
Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID522, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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12
[SID844951]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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13
[SID844951]
Potency 0.5212qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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14
[SID844951]
Potency 4.1475Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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15
[SID844951]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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16
[SID844951]
EC50 HCS for Compounds that Up-Regulate Insulin Promoter Activity in MIN6 Cells [AID1625, Type: confirmatory]
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17
[SID844951]
IC50 HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells [AID1628, Type: confirmatory]
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18
[SID844951]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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19
[SID844951]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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20
[SID844951]
Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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21
[SID844951]
qHTS Assay for Spectroscopic Profiling in Texas Red Spectral Region [AID587, Type: other]
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22
[SID844951]
qHTS Assay for Spectroscopic Profiling in Resorufin Spectral Region [AID588, Type: other]
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23
[SID844951]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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24
[SID844951]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HT1080 cells) [AID620, Type: confirmatory]
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25
[SID844951]
Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [AID626, Type: screening]
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26
[SID844951]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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27
[SID844951]
Isolation of Inhibitors of Her-Kinase Expression - 66K library screen [AID645, Type: screening]
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28
[SID844951]
qHTS Assay for Spectroscopic Profiling in A647 Spectral Region [AID592, Type: other]
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29
[SID844951]
qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral Region [AID593, Type: other]
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30
[SID844951]
qHTS Assay for Spectroscopic Profiling in Rhodamine Spectral Region [AID594, Type: confirmatory]
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31
[SID844951]
qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction [AID595, Type: confirmatory]
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32
[SID844951]
qHTS Assay for Epigenetic Modulators [AID597, Type: confirmatory]
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33
[SID844951]
qHTS Assay for Spectroscopic Profiling in A488 Spectral Region [AID591, Type: other]
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34
[SID844951]
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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35
[SID844951]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
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36
[SID844951]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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37
[SID844951]
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC [AID556, Type: screening]diphosphomevalonate decarboxylase [Streptococcus pneumoniae D39] [gi:116076351]
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38
[SID844951]
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - PMK [AID539, Type: screening]phosphomevalonate kinase [Streptococcus pneumoniae D39] [gi:116077694]
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39
[SID844951]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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40
[SID844951]
Potency qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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41
[SID844951]
Cell Proliferation & Viability (Cytotoxicity) Primary Assay 60K MLSMR [AID463, Type: screening]
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42
[SID844951]
Primary HTS assay for chemical inhibitors of antigen receptor-induced NF-kappaB activation [AID465, Type: screening]
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43
[SID844951]
Ubiquitin-GFP Assay [AID526, Type: confirmatory]
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44
[SID844951]
Counter Screen for Luciferase-based Primary Stimulation Assays [AID1027, Type: screening]
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45
[SID844951]
Image-based Screening Assay for Inhibitors of Phagocytosis [AID1029, Type: screening]
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46
[SID844951]
EC50 High Throughput Screen for Inhibitors of ER Stress-induced Cell Death in a 384 well format. [AID1222, Type: confirmatory]
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47
[SID844951]
Alternative Pathway ELISA_orthogonal screening [AID1235, Type: screening]
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48
[SID844951]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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49
[SID844951]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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50
[SID844951]
Luminescent HTS for small molecule activators of MT1-MMP transcription [AID750, Type: screening]
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