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SMR000012642 (CID 54690395) - Compound BioActivity Data
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BioActivity Outcomes:
Active(32)
 
 
Inactive(804)
 
 
Inconclusive(17)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(555)
 
 
 
 
Confirmatory(271)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(170)
 
 
 
 
 
IC50(59)
 
 
 
 
EC50(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 786    Data Row: 855   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID842207]
EC50 1.72uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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2
[SID842207]
Potency 2.9093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID842207]
EC50 3.1uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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4
[SID85176801]
IC50_Mean 4.92SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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5
[SID842207]
Potency 5.1735qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID842207]
IC50 5.794High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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7
[SID842207]
IC50 7.07uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells [AID2001, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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8
[SID85176801]
IC50_Mean 7.68SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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9
[SID842207]
Absolute IC50 (XBP1) 10XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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10
[SID842207]
Inhibitors of Cav3 T-type Calcium Channels: Primary Screen [AID449739, Type: screening]voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] [gi:53832009]
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11
[SID842207]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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12
[SID842207]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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13
[SID842207]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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14
[SID842207]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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15
[SID842207]
CHOP Confirmatory Screen [AID504437, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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16
[SID842207]
Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]anoctamin-1 isoform 1 [Mus musculus] [gi:334278898]
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17
[SID842207]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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18
[SID842207]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
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19
[SID842207]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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20
[SID842207]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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21
[SID842207]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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22
[SID842207]
Leishmania major promastigote HTS [AID1063, Type: screening]
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23
[SID842207]
Human Fibroblast Cell Proliferation Assay - Dose Response [AID821, Type: confirmatory]
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24
[SID842207]
Human Endothelial Cell Proliferation Assay - Dose Response [AID822, Type: confirmatory]
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25
[SID842207]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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26
[SID842207]
Screen for Chemicals that Extend Yeast Lifespan, Dose Response [AID809, Type: confirmatory]
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27
[SID842207]
Screen for Chemicals that Extend Yeast Lifespan [AID775, Type: screening]
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28
[SID842207]
Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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29
[SID842207]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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30
[SID842207]
Allosteric Modulators of D1 Receptors: Confirmation Screen [AID642, Type: other]
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31
[SID842207]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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32
[SID842207]
Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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33
[SID842207]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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34
[SID842207]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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35
[SID842207]
Potency 0.0071qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]pyruvate kinase PKM isoform a [Homo sapiens] [gi:33286418]
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36
[SID842207]
Potency 3.5481qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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37
[SID842207]
Potency 6.3096qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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38
[SID842207]
Absolute IC50 (CHOP) 7.31CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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39
[SID842207]
Potency 12.5893qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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40
[SID842207]
Potency 14.1254qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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41
[SID842207]
IC50 20HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction [AID2485, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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42
[SID842207]
IC50 20uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD2 cell inhibition assay [AID1848, Type: confirmatory]
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43
[SID842207]
IC50 20uHTS Fluorescence assay for the identification of cytotoxic compounds among compounds active in NOD1 cell inhibition assay [AID1849, Type: confirmatory]
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44
[SID85176801]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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45
[SID842207]
HTS to identify inhibitors of TNF-alpha Induced Cell Death in Jurkat FADD-/- Cells. [AID463075, Type: screening]
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46
[SID842207]
Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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47
[SID842207]
Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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48
[SID842207]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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49
[SID842207]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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50
[SID842207]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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